Showing posts with label Controlled Ovarian Stimulation. Show all posts
Showing posts with label Controlled Ovarian Stimulation. Show all posts
IVF journey x Eggs Collection
2/01/2018 04:33:00 PM
Do you know what eggs collection is?
Say simply, it is collecting good quality oocytes to freeze them. When the number of good oocytes is collected a certain number, starting to thaw these oocytes and then fertilize them.
What kind of situation that women need egg collection?
Let’s me tell you. We all know that ovarian function depends on women’s’ age. As the ages grow, ovarian function begins to decline. Also, the quality of oocytes is gradually getting worse.
Then how do we know our ovarian situation?
There is one important index called Anti-Mullerian hormone (AMH) which is produced by small growing follicles and granulosa cells in ovary we can refer to.
Based on this index, we learn that AMH can be represented as the ovarian situation.
As result, on condition that our AMH is low, we have to seize the chance to collect the good quality oocytes while our ages are not too old (under 38 years old).
*If our age is more than 38 years old, that is completely another thing. What We should do is Blastocyst Collection, not egg collection.
*If our age is more than 38 years old, that is completely another thing. What We should do is Blastocyst Collection, not egg collection.
Besides AMH, age can also convey the important sign to us. How many mature oocytes are enough for women to have a baby?
There is an index as below:
In view of this index, we should go further to know how to distinguish which oocytes are mature.
At first, we judge the cumulus-oocyte complex initially from I to III. Then by using enzyme to remove the cumulus, we can evaluate oocyte morphology and choose the oocytes which are in stage MII to frozen it.
*Only oocytes which are in stage MII is valuable and can be fertilized.
For whom is under 38 years old, the best way to enhance the pregnancy rate effective is egg collection.
According to these two indexes which is related to individual ovarian function, we will apply the individualized controlled ovarian stimulation (iCOS) to design the fittest protocol for each customer.
Besides the individually tailored treatment, we have the most simple and effective process for a customer who far from overseas.
The first time you come to Taiwan is for filling the relevant document and having a necessary examination such as hysterosalpingogram (HSG), and blood drawn. Subsequently, you would bring the injection and medicine back to your home. However, you don’t need to worry. There is a consultant would teach you how to operate the injection and take medicine.
When the treatment starts, what you should do is having blood drawn and taking ultrasound on a specific day in your country for checking the development of follicular.
By checking the report with the consultant and doctor, the doctor would decide the date for oocytes retrieval.
The second time you come to Taiwan is for oocytes retrieval and having the rest of examination such as Hysteroscopy(H-scopy) and Cervical Bacteria Culture (3in 1).
For each eggs collection, you only need to come to Taiwan two times.
If you have further question in your mind, please contact us
for more details or leave a message down below, we are more than willing to answer!
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E-mail：en_service@icryobank.com
WhatsApp：+886-905-737-501Does the mild stimulation improve embryo euploid rate in diminished ovarian reserve women?
8/17/2017 09:27:00 PM
The psychological and financial burden of IVF increases while the ovarian function declines.
If the frequency of injection decreases, would the patients still have enough embryos for transfer?
Eight things to make IVF fail
3/21/2016 03:21:00 AM
What are the causes of IVF failure? Young patients usually get their IVF babies after 1~2 cycles. In the patients over 38 years or with low ovarian reserve, multiple IVF cycles are always necessary. Eight things are common in the patients over 38 years or AMH < 2 ng/ml.
Eight things to make IVF fail
What can we do to the eight things?
Poor response
|
The follicles cannot be stimulated by
external rFSH. It may result in the follicle atresia or growth arrest.
|
Premature ovulation
|
Ovulation in IVF generally occurs 36-40
hours after the triggering. Premature ovulation during IVF results in the
cancellation of oocyte retrieval.
|
Empty follicle
|
Mostly one follicle contains one oocyte.
It is found that there is no oocyte in a follicle after the retrieval.
|
Low oocyte yield
|
Only mature oocyte (MII) can be
fertilized. Nearly 70% of the retrieval oocytes can be used for the following
fertilization in the patients under 35 years; in those over 40 years, the
yield is dropped down to 50% or even lower.
|
Low fertilization rate
|
The general fertilization rate (2PN) in
IVF is around 70%, but it can be lower or complete fertilization failure.
|
Abnormal fertilization
|
Two pronuclear zygote (2PN) is observed
after a normal fertilization. An abnormal fertilization happens while three
pronuclei (3PN) or mutiple pronuclei are observed.
|
Developmental arrest
|
Around 95% of 2PN zygotes grow into the
cleavage stage. Developmental arrest could happen at any time point during
embryo mitosis, e.g. one-cell arrest, 2-4 cells arrest, 6-8 cells arrest,
arrest at compaction stage...etc.
|
Low blastocyst
formation rate
|
After five days of culturing, an embryo
undergoes cell proliferation and differentiation to become a blastocyst. No
blastocyst formed or no blastocyst with good morphology formed at the end of
culturing happened in IVF sometimes.
|
Poor response
|
Individualizing stimulation protocol by adjusting with
maternal age is a method, such as mild stimulation, natural cycle, or
multiple retrievals in a IVF cycle.
|
Premature ovulation
|
Individualizing the time of triggering and retrieval by
adjusting with maternal age, follicle size, and total follicle count.
Non-steroid anti-inflammatory drugs (NSAIDs), which was reported to prevent
premature ovulation in the previous data, can be applied 8~14 hours before
the retrieval as well. For an example, the trigger shot may be injected while
the follicle reaches to 17 mm in diameter to the patients under 40 years, but
it may be injected while the follicle reaches to 15~17 mm in diameter to those
over 40 years to prevent the premature ovulation.
|
Empty follicle
|
It cannot be avoid if the empty follicle forms
naturally.
|
Low oocyte yield
|
The patient can undergo multiple IVF cycles to harvest available
oocytes (oocyte accumulation).
|
Low fertilization rate
|
The quality of sperm and oocyte could be the reasons.
The ICSI/IMSI can be applied to select the sperm with better morphology. Of
the quality of oocyte, it cannot be solved due to the effect of maternal age.
|
Abnormal fertilization
|
If it resulted in abnormal fertilization (3PN or
multiple PNs) while the ICSI/IMSI had been applied, the quality of oocyte
could be the main reason. Oocyte accumulation by multiple IVFs is the only
solution.
|
Developmental arrest and Low blastocyst formation rate
|
Similarly, developmental arrest or no available
blastocyst formed during culturing occurs spontaneously and cannot be avoid.
Embryo accumulation by multiple IVFs is the only solution.
|
Freeze My Eggs — iCryobank
9/14/2015 03:00:00 AM
When can I
meet my Mr. Right?
When can I have my own family?
When can I have my babies?
Except waiting for the one, what can I do now?
Oocyte cryopreservation - the best way
to preserve your fertility.
When can I have my own family?
When can I have my babies?
Except waiting for the one, what can I do now?
Oocyte cryopreservation - the best way to preserve your fertility.
It is popular to donate the eggs during summer vacation
8/18/2015 06:21:00 PM
In Taiwan, the compensation fee for egg donors is NTD 99,000 (USD 3,056). By this considerable compensation fee, some donors were able to join the study-tour, travel abroad, or open their own stores.
According to the local news, the egg donation became more popular in the young females recently. Due to the network convenience, more and more people got the information of egg donation easily, and the enrollment is to double during the summer vacation. Amy just completed her donation program, and she immediately recommended the program to her twin sister. She believed that the donated eggs could help the infertile couple to have their own babies. In this program, she has not only checked her physical status, especially the ovarian function, but also got more understandings to the IVF.
However, the risk of egg donation must be concerned before starting the program. The ovarian hyperstiumulation syndrome (OHSS) is most common in the young females undergoing the controlled ovarian stimulation (COS). An experienced specialist, a stable system of follow-up care, and a reputable fertility center are prior consideration to donate your eggs.
How to avoid the ovarian hyperstimulation?
1. Use GnRH anagonist as the trigger, such as Decapetyl
2. Drink lots of water to dilute the hormone in the body (>2000 ml per day)
3. Take more rest and no strenuous exercise
4. Low-salt and high-protein eating plan
5. Contact with the center whenever you feel uncomfortable
6. Follow-up exams at the center (CBC, ultrasound...)
⬛ Know more about Taiwan egg donation (Chinese Version)
⬛ Want to enroll?
⬛ Share your experiences on Facebook
Call for consultants at +886-3-573-3355 ex. 1523/1522
⬛ Know more about Taiwan egg donation (Chinese Version)
⬛ Want to enroll?
⬛ Share your experiences on Facebook
Call for consultants at +886-3-573-3355 ex. 1523/1522