Prolutex 25mg
1/31/2021 03:49:00 AM
Prolutex (progesterone) Injection is a type of female hormone given to replace the hormone progestin when the body is not making enough of it.
We Stork Fertility Center now provide Prolutex, the other option to supplement enough progesterone on pregnant women. The medicine works on the lining of the womb and helps women stay pregnant, especially at the very beginning of pregnancy.
Dosage
Once daily injection of 25 mg is suggested. Treatment with Prolutex (progesterone) Injection should be initiated under the supervision of a physician experienced in the treatment of fertility problems.
Method of administration
Prolutex (progesterone) Injection is given by subcutaneous (25 mg) or intramuscular (25 mg) injection. We Stork Fertility Center suggest subcutaneous injection on the abdomen.
The Step as below,
Choose an appropriate area on the lower abdomen
Cleanse the injection site with an alcohol pad from the inside out.
Take a pinch of skin and insert the needle at a 90-degree angle to the skin.
Inject the entire amount of medication and stay still for ten seconds.
Pull out the plunger horizontally.
Press the site for 5-10 seconds and do not rub the injection site.
Special precautions for storage
Store below 25°C. Do not refrigerate or freeze.
Store in the original package in order to protect from light.
Side effects
pain and swelling at injection site, breast tenderness, headache, weight gain or loss, acne, nausea, increased body or facial hair, loss of scalp hair, drowsiness, or
dizziness.
If you have any serious side effects from progesterone injection, please tell your physician right away.
Arixtra 2.5mg/0.5 ml
1/29/2021 02:19:00 AM
Arixtra 2.5mg/0.5 ml
(fondaparinux sodium)
What is Arixtra used for?
Arixtra is used to
prevent venous thromboembolic events (problems due to the formation of blood
clots in the veins).
How to inject Aritra
How does Arixtra work?
Blood clotting can be a problem when blood
flow is disturbed in any way. Arixtra is an anticoagulant: it prevents the
blood from coagulating (clotting). The active ingredient in Arixtra,
fondaparinux sodium, stops one of the substances that are involved in the
clotting of blood, factor Xa. When this is blocked, no thrombin (another
factor) can be produced, and no clot can be formed.
Common side effects of Arixtra include:
·
bleeding
problems.
·
bleeding,
rash, and itching at the injection site.
·
severe
bleeding after surgery.
Preservation
of Arixtra
Keep it
below 30 degrees Celsius. No need to refrigerate.
Register：Oversea Form
Facebook：e-Stork FB Page
E-mail：en_service@icryobank.com
WhatsApp：+886-905-737-501
Is ooplasm matured? Polscope, a great helper of IVF
10/27/2020 07:08:00 PM
Spindle of every oocytes is like heart of human. Although we can't see it, it plays the most important role. Stork fertility center list out some groups that are suitable to use polscope to observe spindle.
Under microscope, our embryologists pick out a sperm with great activity
and morphology then inject it into an oocyte. During this process, the polar
body will be placed at 12 o'clock direction to avoid the invisible heart of
oocyte-- spindle. It is formed by microtubules, centrosomes and chromosomes. In
the procedure of cell division, spindle leads chromosomes to separate from the
middle of cells to bipolar. According to scientific studies, spindles are not
right under polar bodies. There are about 30% of oocytes will have the
situation of spindle deviation. Therefore, it might be damaged in regular
operating mode. Which leads to chromosome abnormal and affect development of
embryos. It's like heart of human. We can't see it from outside but it plays
the most important role.
Here are the statistic results from other center. It is shared in 2019 annual
meeting of Taiwanese Society of Reproductive Medicine.
- From 2018.09 to 2019.05
- 31 IVF clients. (31cycles)
- 114 mature MII oocytes
- observe the oocyte spindle 4-6 hours after oocyte retrieval
- With the first polar body as the center, define its left and right 45 degrees as zone A, and the rest as zone B.
The research team finds out the following points.
- We can successfully observe 75%
oocyte spindle 4-6 hours after oocyte retrieval. And there's no difference for
clients above or under 40 years old.
- Most of oocyte spindle (81.4%)
are under first polar body. But there is still 18.6% possibility that spindle
of oocyte will shift and not fall below first polar body.
- Compared with those under 40,
the probability of spindle falling into zone B is higher (27.8% v.s. 16.9%) among
those ≥40 years old. (See the figure and the table
below).
|
|
<40 years old |
≥40 years old |
|
cycles |
20 |
11 |
|
Matured oocyte number(MII) |
86 |
24 |
|
Spindle visible |
75.6% (65/84) |
75% (18/24) |
|
Spindle invisible |
24.4% (21/86) |
25% (6/24) |
|
spindle falling into zone A |
83.1% (54/65) |
72.2% (13/18) |
|
spindle falling into zone B |
16.9% (11/65) |
27.8% (5/18) |
Compare
the culture results of those oocytes that use polscope to observe spindle before ICSI and without observation, it shows
that there are no difference. However, the group that's over 40 years old have
the better fertilization rate. And the division rate can reach to 100% for Day
3.
|
|
With confirmation of the spindle position |
Without confirmation of the spindle position (Assuming it is directly below the first
polar body) |
P-value |
|
Fertilization rate (normal fertilization number/matured oocyte number) |
|||
|
Total (regardless of age) |
72.8% (78/107) |
71.4% (85/119) |
NS |
|
<40 years old |
72.6% (61/84) |
71.4% (75/105) |
NS |
|
≥40 years old |
73.9% (17/23) |
71.4% (10/14) |
NS |
|
Division rate (division embryo numbers/
normal fertilization numbers) |
|||
|
Total (regardless of age) |
6.2% (75/78) |
94.1% (80/85) |
NS |
|
<40 years old |
95.1% (58/61) |
94.7% (71/75) |
NS |
|
≥40 years old |
100% (17/17) |
90% (9/10) |
NS |
Stork Fertility Center
introduced spindle polscopes in 2017 to confirm the maturity stage of the oocytes.
Because oocyte that just spit out first polar body needs another 2~3 hours to
reach the best fertilization time, Metaphase
II. The observation of the spindle can avoid the oocytes which look mature from
appearance (the polar body has been spit out), but the ooplasm is still in the
late phase of the first meiosis (telophase) or those immature oocytes which are
in prophase of second meiosis. So embryologists can control more accurately about
the time to do insemination and avoid to freeze oocytes in telophase (the
spindle is still framed between the ooplasm and the first polar body). Because
the dehydration and shrinkage in the freezing process may cause fracture and
damage of the spindle.
Register：Oversea Form
Facebook：e-Stork FB Page
E-mail：en_service@icryobank.com
WhatsApp：+886-905-737-501
Want to meet you so bad! After repeated implantation failure(I)
9/30/2020 05:33:00 AM Want
to meet you so bad!After
repeated implantation failure(I)
Do you have the experience of repeated
implantation failure in IVF program? Or even though after pregnancy, still
undergo miscarriage or fetal demise? In these situation, the most important thing
to do is try to find out what factor is the "murder" of your child.
What's the most sorrow thing on the
journey to get a baby?
Taiwanese
celebrity汪用和 use fourteen years trying to get a baby. The other celebrity黃光芹 said "The hardship on the journey for getting a baby is like
dying for several times ." They both decide to adopt a child in the end.
And there are still a lot of people keep going on this journey. Such as super
model 林志玲, celebrity 張秀卿 and
the one who read this article without giving up. How can we do for next step to
get to the happy ending?
Want to meet you so bad! It's OK that
if you have a meeting with others but they cancel it at the very end. You can
just rearrange it. However, what will you feel if they disappeared without
saying why?
Friends that break their promise do
not worth profound friendship. And what if this happen on your journey of
getting a baby? Is it trustworthy to use the same treatment after repeated
implantation failure without knowing the reason of failure?
Changing to another scenario. Getting pregnant
every time after implantation but every fetus couldn't keep growing then get
abortion is already miserable enough. When hearing a physician say "let's
try harder next time" what will you feel? How can you bare this twice or
even three times in a row?
If you run on the wrong road, you will never reach the end.
When you fail after two implantation
or getting abortion twice in a row. It means "the murder" is still
there. The most important thing to do at this point is to stop the pace and try
to find out "the murder".
Everything happened for a reason. I
always believe that you must have done something right to lead to success. In
other hand, there might be something wrong lead to failure. If we find out the
factor precisely and exclude it in next treatment, there's no reason that we
will fail next time.
Clients are our teacher. That's also
why I like to use real stories to share with others. Following I'll take three
clients that left our center with smile of success for example.
39 years old Mrs. A
When A came to our center for the
first time, she already underwent two times of implantation failure. First time
was IVF with preimplantation genetic screening(PGS). After failure, doctor
suspect that window of implantation is not right. Therefore, she underwent Endometrial
Receptivity Analysis(ERA). It turns out that she needs to take progesterone for
one more day to get right implantation window.
For the second implantation, with the
right time and prevention Heparin injection. She got pregnant successfully. However, the fetal heat
beat stopped when it was 8 weeks. She remembered clearly that after first and
second implantation, she got bleeding for both time. The blood test of
autoimmune and Thrombosis were normal. Therefore, doctor declined
the dosage of Heparin from two days a time to three days
a time. Meanwhile add progesterone injections. Sadly, the baby is still gone.
The most painful fact is not miscarriage, but not knowing "who killed
my child?''
· We
restarted the oocyte retrieval again, but there were no chromosomally normal embryos.
Can mosaicism(embryos have
both normal and
abnormal cells) embryo be an option of implantation? How can we success with two-third of embryo chromosome abnormal rate
at her age? With my own experience, if there is bleeding situation after
implantation and before pregnancy test, it might because of Thrombus problem.
We rechecked related blood tests and as expected they were weakly-positive.
Therefore, we adjusted Heparin dosage to
one time a day. Today, she is pregnant for14 weeks and 3 days. After hearing the heartbeat, it's time to say
goodbye. Finally, She can be transferred to Obstetrician.
45 years old Mrs. B
Before Mrs. B came to our center, she
already underwent three times of both oocyte retrieval and transfer. Fresh
embryo transfer for the first two times and frozen embryo transfer for the
third time. It's a pity that the embryos were all only cultured to day 3 early
embryos. Which makes it hard to analyze the possible reason for failure. She
was 44 years-old when she came to our center. Oocyte donation program should be
a better choice for her. However, she rejected and choose to use her own eggs.
She collected four embryos that was not proper to do biopsy and then
transferred for the fourth time. She also did ERA before her transfer. However,
she failed again.
Then she changed her mind to do donor
program, to try for her fifth time. After transferred one chromosomally normal
embryo, with ERA test, she still failed. Were there still other
"murders" out there?
We checked all her autoimmune and Thrombosis blood tests again. And found
out her Nephelometry IgG
result was higher than reference. The only difference between sixth transfer
and fifth transfer is that we gave her Intravenous immunoglobulin(IVIG)
injection three days before transfer. And started heparin injection one time a
day from her transfer date. Now, she is pregnant for eleven weeks and one day.
We are so happy for her.
45 years old Mrs. C
Before Mrs. C came to our center, she
already failed for three times. She wouldn't want to try traditional IVF.
Before our suggestion, she decided to do 3+ IVF( with PGS and ERA). She got
pregnant after first transfer. Although she had some bleeding during her eighth
week but baby heartbeat was normal at that time. With normal Thrombosis blood tests,
progesterone injections and pills. When she came back after two weeks, the fetus
is still growing. However, the fetus stopped growing next week unexpectedly. It
was a real bolt from the blue that made her heart broke. Isn't it comparably
safe after 10 weeks? Moreover, it is 3+ IVF this time!
My detective instinct told me it might
be Thrombosis problem due to the
bleeding situation after transfer. Therefore, I added two blood tests to be monitored
this time. All tests were normal on the pregnancy test date. And there were no
bleeding situation before fetal heartbeat check. We checked Thrombosis blood test for one more time
and accidently found that one of the test became to abnormal. We immediately
increased the dosage of heparin form two days a time to everyday. Now she is pregnant for eleven weeks and four days.
Congratulations to her for finally finding the hiding murder and say goodbye to
those misery days after failure.
Clients
are our teacher
Mrs. A gave us two lessons.
First lesson- please don't ask "should I do ERA test?"
anymore.
Second lesson- If there are bleeding situation during pregnancy,
please beware that Thrombosis might be killing your child.
Don't just think of taking progesterone injections.
Mrs. B
also gave us two lessons.
First lesson- Over 43 years-old should choose oocyte donation
program directly. Don't waste money.
Second lesson-Infertility doctors should accept humbly that there
are some people who have immune system problems that will lead to the system attacking
embryos causing reimplantation failure.
Mrs.
C gave us two lessons that's more valuable.
First lesson- follow only one Thrombosis test is not enough. It is more accurate to test two
at the same time.
Second lesson- Today's result is not able to represent tomorrow's.
The data of two Thrombosis tests
were normal, and the fetal heartbeat also appeared as expected after 3 weeks.
But why the Thrombosis test
became abnormal? Our body situation is dynamic. If you are healthy today do not
represent you won't get sick tomorrow.
Think
about why these three teacher pay for sky-high price to learn these before
success in their tough journey.
If you ask me where is the cheapest
place to do IVF? I won't answer! Because there's always a cheaper place.
But if you change the question to
"How to bring a healthy baby back home with the least hardship and most Cost-effective?'' I'll answer you without any
doubt-- 3+ IVF! Because you can get 80% of successful rate with only one embryo
transfer. We design your own personal precisely IVF treatment and every step is
based on evidence. After failed
unfortunately, we can also check from the very end to see is there any possible
factors that become the "murder". Different from traditional IVF,
using your own body to do "experiments".
Want to meet you so bad! Stork
Fertility Center likes to choose a challenging path! This year is our 20th anniversary.
We open a special appointment "Reimplantation Failure appointment".
Please don't come if you like to chat or heard that Dr. Lai is not patient to
clients. But for those who already traveled around the world and are longing to
become parents as soon as possible, please come to join this journey. It's better that you believe in
"precise treatment", knowing that everything happens for a reason and
believing that you will only success when you are on the right track!
Register：Oversea Form
Facebook：e-Stork FB Page
E-mail：en_service@icryobank.comWhatsApp：+886-905-737-501
Do you have the experience of repeated
implantation failure in IVF program? Or even though after pregnancy, still
undergo miscarriage or fetal demise? In these situation, the most important thing
to do is try to find out what factor is the "murder" of your child.
What's the most sorrow thing on the journey to get a baby?
Taiwanese celebrity汪用和 use fourteen years trying to get a baby. The other celebrity黃光芹 said "The hardship on the journey for getting a baby is like dying for several times ." They both decide to adopt a child in the end. And there are still a lot of people keep going on this journey. Such as super model 林志玲, celebrity 張秀卿 and the one who read this article without giving up. How can we do for next step to get to the happy ending?
Want to meet you so bad! It's OK that
if you have a meeting with others but they cancel it at the very end. You can
just rearrange it. However, what will you feel if they disappeared without
saying why?
Friends that break their promise do not worth profound friendship. And what if this happen on your journey of getting a baby? Is it trustworthy to use the same treatment after repeated implantation failure without knowing the reason of failure?
Changing to another scenario. Getting pregnant every time after implantation but every fetus couldn't keep growing then get abortion is already miserable enough. When hearing a physician say "let's try harder next time" what will you feel? How can you bare this twice or even three times in a row?
If you run on the wrong road, you will never reach the end.
When you fail after two implantation or getting abortion twice in a row. It means "the murder" is still there. The most important thing to do at this point is to stop the pace and try to find out "the murder".
Everything happened for a reason. I always believe that you must have done something right to lead to success. In other hand, there might be something wrong lead to failure. If we find out the factor precisely and exclude it in next treatment, there's no reason that we will fail next time.
Clients are our teacher. That's also why I like to use real stories to share with others. Following I'll take three clients that left our center with smile of success for example.
39 years old Mrs. A
When A came to our center for the first time, she already underwent two times of implantation failure. First time was IVF with preimplantation genetic screening(PGS). After failure, doctor suspect that window of implantation is not right. Therefore, she underwent Endometrial Receptivity Analysis(ERA). It turns out that she needs to take progesterone for one more day to get right implantation window.
For the second implantation, with the right time and prevention Heparin injection. She got pregnant successfully. However, the fetal heat beat stopped when it was 8 weeks. She remembered clearly that after first and second implantation, she got bleeding for both time. The blood test of autoimmune and Thrombosis were normal. Therefore, doctor declined the dosage of Heparin from two days a time to three days a time. Meanwhile add progesterone injections. Sadly, the baby is still gone.
The most painful fact is not miscarriage, but not knowing "who killed
my child?''
· We restarted the oocyte retrieval again, but there were no chromosomally normal embryos. Can mosaicism(embryos have both normal and abnormal cells) embryo be an option of implantation? How can we success with two-third of embryo chromosome abnormal rate at her age? With my own experience, if there is bleeding situation after implantation and before pregnancy test, it might because of Thrombus problem. We rechecked related blood tests and as expected they were weakly-positive. Therefore, we adjusted Heparin dosage to one time a day. Today, she is pregnant for14 weeks and 3 days. After hearing the heartbeat, it's time to say goodbye. Finally, She can be transferred to Obstetrician.
45 years old Mrs. B
Before Mrs. B came to our center, she already underwent three times of both oocyte retrieval and transfer. Fresh embryo transfer for the first two times and frozen embryo transfer for the third time. It's a pity that the embryos were all only cultured to day 3 early embryos. Which makes it hard to analyze the possible reason for failure. She was 44 years-old when she came to our center. Oocyte donation program should be a better choice for her. However, she rejected and choose to use her own eggs. She collected four embryos that was not proper to do biopsy and then transferred for the fourth time. She also did ERA before her transfer. However, she failed again.
Then she changed her mind to do donor program, to try for her fifth time. After transferred one chromosomally normal embryo, with ERA test, she still failed. Were there still other "murders" out there?
We checked all her autoimmune and Thrombosis blood tests again. And found out her Nephelometry IgG result was higher than reference. The only difference between sixth transfer and fifth transfer is that we gave her Intravenous immunoglobulin(IVIG) injection three days before transfer. And started heparin injection one time a day from her transfer date. Now, she is pregnant for eleven weeks and one day. We are so happy for her.
45 years old Mrs. C
Before Mrs. C came to our center, she already failed for three times. She wouldn't want to try traditional IVF. Before our suggestion, she decided to do 3+ IVF( with PGS and ERA). She got pregnant after first transfer. Although she had some bleeding during her eighth week but baby heartbeat was normal at that time. With normal Thrombosis blood tests, progesterone injections and pills. When she came back after two weeks, the fetus is still growing. However, the fetus stopped growing next week unexpectedly. It was a real bolt from the blue that made her heart broke. Isn't it comparably safe after 10 weeks? Moreover, it is 3+ IVF this time!
My detective instinct told me it might be Thrombosis problem due to the bleeding situation after transfer. Therefore, I added two blood tests to be monitored this time. All tests were normal on the pregnancy test date. And there were no bleeding situation before fetal heartbeat check. We checked Thrombosis blood test for one more time and accidently found that one of the test became to abnormal. We immediately increased the dosage of heparin form two days a time to everyday. Now she is pregnant for eleven weeks and four days. Congratulations to her for finally finding the hiding murder and say goodbye to those misery days after failure.
Clients
are our teacher
Mrs. A gave us two lessons.
First lesson- please don't ask "should I do ERA test?" anymore.
Second lesson- If there are bleeding situation during pregnancy, please beware that Thrombosis might be killing your child. Don't just think of taking progesterone injections.
Mrs. B also gave us two lessons.
First lesson- Over 43 years-old should choose oocyte donation program directly. Don't waste money.
Second lesson-Infertility doctors should accept humbly that there are some people who have immune system problems that will lead to the system attacking embryos causing reimplantation failure.
Mrs.
C gave us two lessons that's more valuable.
First lesson- follow only one Thrombosis test is not enough. It is more accurate to test two at the same time.
Second lesson- Today's result is not able to represent tomorrow's. The data of two Thrombosis tests were normal, and the fetal heartbeat also appeared as expected after 3 weeks. But why the Thrombosis test became abnormal? Our body situation is dynamic. If you are healthy today do not represent you won't get sick tomorrow.
Think about why these three teacher pay for sky-high price to learn these before success in their tough journey.
If you ask me where is the cheapest place to do IVF? I won't answer! Because there's always a cheaper place.
But if you change the question to "How to bring a healthy baby back home with the least hardship and most Cost-effective?'' I'll answer you without any doubt-- 3+ IVF! Because you can get 80% of successful rate with only one embryo transfer. We design your own personal precisely IVF treatment and every step is based on evidence. After failed unfortunately, we can also check from the very end to see is there any possible factors that become the "murder". Different from traditional IVF, using your own body to do "experiments".
Want to meet you so bad! Stork
Fertility Center likes to choose a challenging path! This year is our 20th anniversary.
We open a special appointment "Reimplantation Failure appointment".
Please don't come if you like to chat or heard that Dr. Lai is not patient to
clients. But for those who already traveled around the world and are longing to
become parents as soon as possible, please come to join this journey. It's better that you believe in
"precise treatment", knowing that everything happens for a reason and
believing that you will only success when you are on the right track!
Register：Oversea Form
Facebook：e-Stork FB Page
E-mail：en_service@icryobank.comWhatsApp：+886-905-737-501
Hesitate no more, Freeze you future now!
9/30/2020 03:16:00 AM
What would you do if you come upon a huge fortune? It is easy to plan how to spend. But what if we are forced to take leave from work for two whole a month with no salary? That is a conundrum.
Dr. Hsin-Hwa Lai, MD
|
Age |
25 or below |
35 |
38 |
40 |
43 or above |
|
AMH |
>6 |
4 |
3 |
2 |
1 |
|
Reminder |
Age lies：For women under 30, up to 8%
are with AMH<2.5ng/mL |
||||
2.Number of
oocytes that you need for 1 baby with IVF at different age:
|
Age |
31~34 |
35~37 |
38~40 |
|
No. of mature egg |
11 |
15 |
20 |
|
Note |
Statistics From Stork
Fertility Center |
||