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Showing posts with label Male factor. Show all posts
Showing posts with label Male factor. Show all posts

Traps from delicious foods? Eat right and have better sperm




Do you like wearing a tight pants or putting your laptop on your thighs? These habits may affect the quality of your sperm. Besides, five types of drinks/foods may harm your reproductive system. Let’s check and keep in mind!

According to <<Epicurious>>, if the quality of your sperm is not good, it may affect your family plan. To maintain the good quality of sperm, the uptakes of following drinks/foods must be controlled.

 1. Alcohol
Alcohols dehydrates the water in our bodies, and increases the risk of obesity, and reduces the mobility of sperms. We suggest not drinking alcohol more than once per week, and therefore the bodies can metabolize the alcohol. But if you have severe reproductive problem, it is better to quit alcohol.






2. Processed meat products
Bacon, ham and burger are delicious, but these processed meat products usually contain high proportion of saturated fat and hormone residues, which harm the quality of sperm. If you like meat, have the “fresh” one.







3. Sweet Drinks
Bubble milk tea or other sweet drinks contain high proportion of sugar stimulating pancreas to release more insulin, and they increases the risk of obesity. Sweet drinks reduce both the quantity and quality of sperm. It’s better for us to drink water.






4. High-fat dairy products
Milk, cheese and other dairy products can provide protein, calcium and other nutrients. But the high fat contained in these products may harm male’s reproductive system. Also, pesticide or hormone residues should be concerned in some dairy products.





5. Fruits with pesticide residues
Some of the fruits or vegetables may have pesticide residues, especially apples, grapes, strawberries, spinach, cucumbers, etc. We suggest choosing organic fruits and vegetables to decrease the risk.





Stay away from bad habits and unhealthy foods/drinks. Get your sperm good! 

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Stork Fertility Center Stork Fertility Center Author

What should we know about male infertility



Like the infertility issues in females, 
male fertility correlates with the age, lifestyle, and individual background. 
If you are aware of these factors, 
you may know more about your own body state.


With the dramatic change in recent society, people tend to start family late. We usually choose to pursue career first, and put starting our own family at the second priority. This decision made more people encounter the infertility problems at their late 30s and 40s of age. More and more studies demonstrated that the quality of oocyte declines with increasing female age. Thus oocyte cryopreservation for the social reason becomes more popular. How about the men? Several studies also found that the mean age of fathering men showed increased since 1993 to date. Meanwhile, the percentage of male factor in the entire population with fertility problem is increasing as well. The following 4 questions are frequently asked by our male cases,





1. Should semen analysis be routinely clinical testing?


Reproductive potential gradually declines with advanced paternal age, but the declining speed is not as fast as maternal ovaries. The semen analysis is the most common method to check the general sperm quality. Some studies indicated that there is significant decrease in semen volume, sperm concentration, sperm motility and sperm morphology among older men. The pregnancy rate in the men at 40s displayed 10% down than that in the men at 30s. Thus the males with advanced age and abnormal semen parameters have higher risk for the infertility issue. Should the semen analysis be routine testing? Maybe NOT. Only the couple who has failed to conceive for ≧1 year is recommended.






2. Should PGS (preimplantation genetic screening) be performed in the men at advanced age? 


The rate of aneuploid embryo is higher in women at advanced age (≧36 years old), and thus PGS becomes an option for them to choose the embryo with normal chromosomal dosage. Is it possible that the aneuploid embryo derived from the sperm with advanced paternal age ? Hassold et al. demonstrated that one of the cause for trisomy 21 is paternal chromosome nondisjunction, and it accounted for 20% of the entire population with trisomy 21. A more-recently scientific article showed that significantly increasing aneuploid rate in embryos from the older men and men with oligozoospermia. It appears that suboptimal sperm can be a source of embryo aneuploidy. However, the correlation of paternal age and embryo aneuploidy is not as strong as that of maternal age. For those with partner at advanced maternal age, or with the recurrent miscarriage history or family inherited disease, PGS/PGD is recommended. Generally, the paternal age is not the sole indication for PGS.





3. What should the older father know?

Several reports showed the children with older fathers are more likely to develop certain pathologies, such as the schizophrenia. The rate of autism spectrum disorders slightly increases as well. For the father themselves, some medical comorbidities do affect the fertility, like heart disease and chronic medicines of hypertension. It could lead to erectile dysfunction and benign prostatic hypertrophy.




4. Should males cryopreserve their sperm for social reason?


The sperm motility could be halved after cryopreservation. For men with known fertile issue, cryopresevation may induce sperm DNA damage. Since the correlation between fertility and male age is not as strong as the female age, there is no need to cryopreserve sperm for the social reason, and the state of frozen sperm is not comparable to the fresh sperm.

Beyond examinations, healthy diet and lifestyle do help the fertility. It's not necessary to cryopreserve sperm at young age. If the body stays good, the quality of sperm may remain for a long time.



Stork Fertility Center Stork Fertility Center Author

Hyaluronan(HA) binding assay: a good matchmaker to sperm



For in-vitro fertilization, the oocytes attract the sperms with better maturation status by hyaluronic acid of the surrounding cumulus cells.






In the 2016 annual meeting of Taiwan Society of Reproductive Medicine, Dr. Dionisios Sakkas from Boston IVF center, US, shared his experiences in semen processing and sperm selection,

1. Density:Gradient separation 

2. Surface Charge:Electrophoresis 


4. Motility Characteristics: Microfluidics

5. Membrane Integrity:Hyaluronan(HA)-binding

6. Surgical:MESA/TESE 


Stork Fertility Center Stork Fertility Center Author

The clinical outcomes of donor sperm bank

The percentage of Stork Fertility Center sperm donation cycles to the total sperm donation cycles in Taiwan:




*The sky-blue bar represents the percentage of SFC oocyte donation cycle, and the sky-blue plus apricot represents the total oocyte donation cycles in Taiwan.


The clinical outcomes of embryo transfer in the donated-oocyte recipients:



* BT= blastocyst transfer
* FBT = frozen (and then thawed) blastocyst transfer
Stork Fertility Center Stork Fertility Center Author

Oocyte activation


We just discussed one issue of male factors in the infertility realm—azoospermia. Actually the entire proportion of male factors in the infertility indications is around 35-40%, and they were divided into the following groups.

 


By using several assisted reproductive techniques, such as intracytoplasmic sperminjection (ICSI) and intracytoplasmic morphologically selected sperm injection (IMSI), the average fertilization rate was raised up to 70%-80%. However, complete fertilization failure or very-low fertilization rate still occurred in around 1-5% of IVF-ICSI cycles. In this case, the issue of incomplete oocyte activation was concerned. The interactions between oocyte and sperm during fertilization was displayed as follows.


Stork Fertility Center Stork Fertility Center Author

Azoospermia



Male factor is one of the important issues in the infertility. Azoospermia is one of the tricky things in the male infertility. If a problem occurred in the procedure of spermatogenesis (sperm production) or sperm transport, it results in azoospermia, which means no sperms found in the ejaculated semen.


Stork Fertility Center Stork Fertility Center Author

Are you afraid of testicular sperm extraction (TESE)?


Before starting the IVF program, the diagnostic microdissection testicular sperm extraction can improve the success rate of surgical sperm extraction on the oocyte retrieval day. It would be a great news in the couples with azoospermia.

Stork Fertility Center Stork Fertility Center Author

Should I use Intracytoplasmic Sperm Injection (ICSI)? (ICSI in Taiwan)


Due to the changes of global climate and general living style, the quality of male sperm, including the morphology and the mobility, has become worse and it also decreased the fertilization rate in the IVF realm. Nowadays, intracytoplasmic sperm injection is the most common technique at ART labs ...


(Source: http://www.goivf.com/treatment-options/ivf-process/male-factor-icsi-tese/ )






Traditional treatments to the fertility problems caused by male factors were limited before 1992. It takes about 74 days to generate mature sperms at testes, so these male patients also needed to take such the same time to receive stimulation injections or oral medications. Thus their patience and perseverance were really the challenges to whom were eager to be fathers. Things were dramatically changed in 1992. Belgium doctor, Dr. Gianpiero Palermo, successfully fertilized the oocytes through Intracytoplasmic Sperm Injection (ICSI) and brought all the IVF patients to another milestone. 





What is Intracytoplasmic Sperm Injection?


ICSI is to inject a single sperm with good shape and mobility into a mature egg (MII oocyte). Though this technique is developed for those with poor quality of sperms, it has become very popular for general IVF cases recently. Then many people may have the question about the appropriate conditions to use ICSI.


Stork Fertility Center Stork Fertility Center Author

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