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Oocyte spindle and embryo ploidies

From oocyte retrieval to blastocyst cryopreservation, the best timing to do fertilization is always an important issue in the IVF realm. The techniques of ICSI, or IMSI, can help the embryo technician select the sperm with the best morphology to increase the fertilization rate. After the development of spindle microscope (an modified microscope which can observe the spindle of oocyte), the question of "when to fertilize?" has emerged.

In the newly-released article of Science, the author explained the reason of higher chromosomal aneuploidy in human oocytes in comparison with the other human somatic cells, and mouse oocytes. Holubcova el al. developed a time-lapse system combing with vital stain of human oocyte to record the oocyte maturation process (from GVBD to MII).

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The procedure of sperm donating IVF

Step 1. Paper Work
For registration of IVF related treatments (e.g. autologous IVF, oocyte-donating, sperm-donating ...) in Taiwan, the Department of Health Promotion Administration
required paper works as follows,

a. Two forms of picture IDs (Your passport must be necessary)
b. Certificate of Marriage which must be certified by Overseas Office of Republic of  China, Taiwan
c. Agreements of IVF/Oocyte Recipient/Sperm Recipient programs

(Notes: If you are taking an sperm donating cycle, both agreements for IVF treatment and sperm recipient are required.)

Step 2. Examinations
Before starting the main treatments, several checkup exams must be done to confirm the uterine condition and male factors. They are listed as follows, (You can provide the clinical reports at your local hospitals, or just take the exams when you visit Stork Fertility Center. )

a. Sperm Analysis
b. Hormone tests (AMH, TSH, PRL, FreeT4 ...)
c. Hysteroscopy (The clinical report within half year is more recommended.)
d. Hysterosalpingography (The clinical report within half year is more recommended.)
e. Cervical culture (Chlamydia DNA test and HPV test are also recommended.)
f. Sperm Cryopreservation: If your spouse cannot visit us on the oocyte retrieval date, it is better to preserve his sperm sample in advanced.
g. Bring the prescribed medicines

(Notes: You may spend two to three days staying in Taiwan to complete the exams and required documents. For this visitation, it's necessary for both you and your husband.)

The procedure of undergoing sperm donating IVF is as follows,

If you choose the frozen blastocyst transfer, the procedure is as follows,

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A patient friendly corifollitropin alfa protocol without routine pituitary suppression in normal responders

Huai-Ling Wang1, Hsing-Hua Lai1, Tzu-Hsuan Chuang1, Yu-Wei Shih1, Shih-Chieh Huang1, Meng-Ju Lee1, Shee-Uan Chen2
1Stork Fertility Center, Stork Ladies Clinic, HsinchuTaiwan (R.O.C)
2Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, TaipeiTaiwan (R.O.C)
Corifollitropin alfa;  Controlled ovarian stimulation;  GnRH antagonist


Reducing the frequency of injections in an in vitro fertilization (IVF) program is a patient-friendly way to decrease the mental stress and financial burden in infertile couples. The release of corifollitropin alfa simplifies daily injections of short-acting recombinant follicular stimulating hormone (rFSH), and its widely-used protocol involves short-acting gonadotropins supplements and a fixed GnRH antagonist regimen, largely based on follicle size. In this study, the feasibility of corifollitropin alfa without routine pituitary suppression was evaluated, and it may further simplify the injection protocol.

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