Turner Syndrome; My IVF journey
12/31/2020 12:00:00 AMIt turns out I have Turner's disease. Getting Pregnant with chromosomal abnormalities?
Author: Case sharing
Looking at you, deeply asleep next to me. I just want to kiss your over and over again and tell you how much I love you. Thinking about what have I been through, it's been hard and difficult. I want to share my experience with you who are still struggling as I did. Never give up, the best is yet to come!
I have been married to my husband for three years and tried all the methods that we can find on the Internet trying to get pregnant. The pregnancy test never appears with 2 lines each month. Eventually, I started my IVF journey. But it hit me with a big surprise.
I remember I was just doing a routine ultrasound exam. I didn’t worry too much. The doctor explained the result to me afterward. He suggested AMH and chromosome test for me as I have very few antral follicle counts. That concluded my first clinical visit experience. I got my reports later on. My AMH was only 0.07, equivalent to the value of menopause. And I have some abnormalities on my chromosome. I was sitting in my car, I cried for a very long time. I thought that I can't have my own child.
My husband loves me very much, by knowing the news, he just asked me if it would affect my health. I said no. He said that's fine then, the only thing that matters is you. I wept again after hearing him saying that. From that moment on, I swore to myself, I will hold on to any slightest chance that I can find. Even if that means I will have to suffer.
I have visited all fertility centers in Beijing, both public and private, and received two hysteroscopy exams and one salpingography.
I have to do injections every month and do ultrasounds to monitor the growth of the follicles. And if there is a chance to retrieve the eggs, I always say yes.
After 2 years, I don’t know how many injections and blood tests I had. The only thing I remembered was the bruises on both arms. The nurse couldn’t even find a spot for a new test. After going through everything, only 2 embryos can be transferred at last. It didn't end as I expected. I know that I can not do this anymore, I won't work.
The only choice left is using an egg donor. I know that many of you might reject the idea of using an egg donor at first. So do I. But after you've tried everything and I just won't work, it's time for you this think of another solution.
I started to browse all kinds of information about egg donors on the Internet and kept doing consultations online. But the more I watched, the more I hesitated. Too many people have been deceived. Without personal experience, I don't dare to take the step.
I found relevant information about Stork Fertility Center on the Internet. I didn’t pay special attention at first because it's quite far away. And it's hard for me to verify the authenticity of the center. Until a friend of mine was also seeking a way to donate eggs in Taiwan due to genetic problems, and chatting about Strok, she said that her friend had already been there, the experience was amazing. And the successful pregnancy rate was very high, 90% of the people are all successful the first time!
She invited me into a chat group about Stork, and I was so excited. I finally saw the silver lining. I was browsing all the discussions in the group and saw pictures of their babies, I've decided.
In September 2017, I sent an email to Stork and received a call the next day. The contact person was Joanna, she is very kind, and her voice is very soft and nice. She listened very carefully to all my questions, encouraged me, gives me confidence, answered all my questions and all my worries. It makes me feel very warm. Since then, I have communicated with Joanna through email. She told me detailed information before going to Taiwan. I do not need to worry about a thing at all.
In October, I finished the required notarization and started to go through various formalities for going to Taiwan. And then I was waiting for my period to come. Unexpectedly, my cycle was late. It was fairly regular, I didn't have my cycle for a month in November. During the time, I was very scared and terrified and kept in touch with Joanna by email. She told me not to hurry, wait slowly. It's not like you are having medical treatment, more like talking to a close friend. Not only giving some professional advice but also understand how you feel at the moment and relieve your original anxiety and irritability due to illness.
In mid-December, my period finally came. And my impression of Stork Fertility Center was amazing! I was stunned by their environment, their service, and their profession. From the moment I got off the taxi, I felt the warmth from the staff, they were so welcoming. Joanna accompanied me through all the treatments of the day. I met Dr. O, an elegant, handsome, kind doctor. Dr. O carefully analyzed our previous experience and my medical history. Hysteroscopy and salpingography were arranged by Dr.O. Although I have done countless IVF treatments in Beijing, I still felt nervous every time I lie on the ice-cold operating table.
They noticed that I was nervous and held my hand during the whole process. They also told me that I could hold on to her hard if I wanted. That was so moving. I almost cried. When the blood was drawn, the nurse would also gently say: "Excuse me, it hurts a bit, I will be gentle."
After the examination, the uterine cavity environment was not good, with polyps and fibroids. Dr. O suggested that we go back to Beijing and treat for the uterus cavity before doing implantation surgery.
After returning to Beijing, I received hysteroscopic surgery again. One month after that, I received an email telling me that they found a matching egg donor for me. In March 2018, the donor entered the egg retrieval treatment. They retrieved 20 eggs, all 20 eggs were fertilized, and created 14 blastocysts! It made me admire the technology of Stork! In June, I successfully transplanted 2 blastocysts, one 5BB with PGS and one 5BC without PGS. The good news came 14 days later. The pregnancy went smoothly, and we successfully recorded the baby's heartbeat at 7 weeks of pregnancy. Holding the report, I looked at it for a long time, the long-awaited baby is growing up smoothly inside me.
Unfortunately, the child was found with a cleft lip during the fifth-month pregnancy. My heart was broken and I sent an email to Joanna. The call came right away and arranged for Dr.O to call me at night. I remembered that we talked for a long time that day. Dr. O analyzed the consequences of leaving and not leaving this baby.
Finally, he told me no matter what decision I make, just don't regret it. If we keep the baby, take good care of the baby, and accompany her through every difficult moment she will face. If you don’t keep the baby, you must believe that the baby will come back to me in good health. When Dr.O analyzed my problem so carefully and listen to my heart, I felt encouraged.
Finally, in November 2018, my husband and I farewelled our baby in tears. Although we were reluctant to give up, we were worried that she would face many difficulties in this world.
After communicating with Dr. O, I started the second transplantation course in April 2019. I got pregnant again 14 days later. In December 2019, my baby was born smoothly and healthily. At this moment, she is lying next to me and sleeping. I believe Dr. O's words, my baby is back. People who know my experience say that I am not easy, yes, that's true. Now I am very grateful, I am grateful that I met my husband who loves me, I am grateful that I met Stork Fertility Center. I am grateful that I met Dr. O. Thank you.
E-mail：en_service@icryobank.comWhatsApp：+886-905-737-501
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Want to meet you so bad! After repeated implantation failure(I)
9/30/2020 05:33:00 AM Want
to meet you so bad!After
repeated implantation failure(I)
Do you have the experience of repeated
implantation failure in IVF program? Or even though after pregnancy, still
undergo miscarriage or fetal demise? In these situation, the most important thing
to do is try to find out what factor is the "murder" of your child.
What's the most sorrow thing on the
journey to get a baby?
Taiwanese
celebrity汪用和 use fourteen years trying to get a baby. The other celebrity黃光芹 said "The hardship on the journey for getting a baby is like
dying for several times ." They both decide to adopt a child in the end.
And there are still a lot of people keep going on this journey. Such as super
model 林志玲, celebrity 張秀卿 and
the one who read this article without giving up. How can we do for next step to
get to the happy ending?
Want to meet you so bad! It's OK that
if you have a meeting with others but they cancel it at the very end. You can
just rearrange it. However, what will you feel if they disappeared without
saying why?
Friends that break their promise do
not worth profound friendship. And what if this happen on your journey of
getting a baby? Is it trustworthy to use the same treatment after repeated
implantation failure without knowing the reason of failure?
Changing to another scenario. Getting pregnant
every time after implantation but every fetus couldn't keep growing then get
abortion is already miserable enough. When hearing a physician say "let's
try harder next time" what will you feel? How can you bare this twice or
even three times in a row?
If you run on the wrong road, you will never reach the end.
When you fail after two implantation
or getting abortion twice in a row. It means "the murder" is still
there. The most important thing to do at this point is to stop the pace and try
to find out "the murder".
Everything happened for a reason. I
always believe that you must have done something right to lead to success. In
other hand, there might be something wrong lead to failure. If we find out the
factor precisely and exclude it in next treatment, there's no reason that we
will fail next time.
Clients are our teacher. That's also
why I like to use real stories to share with others. Following I'll take three
clients that left our center with smile of success for example.
39 years old Mrs. A
When A came to our center for the
first time, she already underwent two times of implantation failure. First time
was IVF with preimplantation genetic screening(PGS). After failure, doctor
suspect that window of implantation is not right. Therefore, she underwent Endometrial
Receptivity Analysis(ERA). It turns out that she needs to take progesterone for
one more day to get right implantation window.
For the second implantation, with the
right time and prevention Heparin injection. She got pregnant successfully. However, the fetal heat
beat stopped when it was 8 weeks. She remembered clearly that after first and
second implantation, she got bleeding for both time. The blood test of
autoimmune and Thrombosis were normal. Therefore, doctor declined
the dosage of Heparin from two days a time to three days
a time. Meanwhile add progesterone injections. Sadly, the baby is still gone.
The most painful fact is not miscarriage, but not knowing "who killed
my child?''
· We
restarted the oocyte retrieval again, but there were no chromosomally normal embryos.
Can mosaicism(embryos have
both normal and
abnormal cells) embryo be an option of implantation? How can we success with two-third of embryo chromosome abnormal rate
at her age? With my own experience, if there is bleeding situation after
implantation and before pregnancy test, it might because of Thrombus problem.
We rechecked related blood tests and as expected they were weakly-positive.
Therefore, we adjusted Heparin dosage to
one time a day. Today, she is pregnant for14 weeks and 3 days. After hearing the heartbeat, it's time to say
goodbye. Finally, She can be transferred to Obstetrician.
45 years old Mrs. B
Before Mrs. B came to our center, she
already underwent three times of both oocyte retrieval and transfer. Fresh
embryo transfer for the first two times and frozen embryo transfer for the
third time. It's a pity that the embryos were all only cultured to day 3 early
embryos. Which makes it hard to analyze the possible reason for failure. She
was 44 years-old when she came to our center. Oocyte donation program should be
a better choice for her. However, she rejected and choose to use her own eggs.
She collected four embryos that was not proper to do biopsy and then
transferred for the fourth time. She also did ERA before her transfer. However,
she failed again.
Then she changed her mind to do donor
program, to try for her fifth time. After transferred one chromosomally normal
embryo, with ERA test, she still failed. Were there still other
"murders" out there?
We checked all her autoimmune and Thrombosis blood tests again. And found
out her Nephelometry IgG
result was higher than reference. The only difference between sixth transfer
and fifth transfer is that we gave her Intravenous immunoglobulin(IVIG)
injection three days before transfer. And started heparin injection one time a
day from her transfer date. Now, she is pregnant for eleven weeks and one day.
We are so happy for her.
45 years old Mrs. C
Before Mrs. C came to our center, she
already failed for three times. She wouldn't want to try traditional IVF.
Before our suggestion, she decided to do 3+ IVF( with PGS and ERA). She got
pregnant after first transfer. Although she had some bleeding during her eighth
week but baby heartbeat was normal at that time. With normal Thrombosis blood tests,
progesterone injections and pills. When she came back after two weeks, the fetus
is still growing. However, the fetus stopped growing next week unexpectedly. It
was a real bolt from the blue that made her heart broke. Isn't it comparably
safe after 10 weeks? Moreover, it is 3+ IVF this time!
My detective instinct told me it might
be Thrombosis problem due to the
bleeding situation after transfer. Therefore, I added two blood tests to be monitored
this time. All tests were normal on the pregnancy test date. And there were no
bleeding situation before fetal heartbeat check. We checked Thrombosis blood test for one more time
and accidently found that one of the test became to abnormal. We immediately
increased the dosage of heparin form two days a time to everyday. Now she is pregnant for eleven weeks and four days.
Congratulations to her for finally finding the hiding murder and say goodbye to
those misery days after failure.
Clients
are our teacher
Mrs. A gave us two lessons.
First lesson- please don't ask "should I do ERA test?"
anymore.
Second lesson- If there are bleeding situation during pregnancy,
please beware that Thrombosis might be killing your child.
Don't just think of taking progesterone injections.
Mrs. B
also gave us two lessons.
First lesson- Over 43 years-old should choose oocyte donation
program directly. Don't waste money.
Second lesson-Infertility doctors should accept humbly that there
are some people who have immune system problems that will lead to the system attacking
embryos causing reimplantation failure.
Mrs.
C gave us two lessons that's more valuable.
First lesson- follow only one Thrombosis test is not enough. It is more accurate to test two
at the same time.
Second lesson- Today's result is not able to represent tomorrow's.
The data of two Thrombosis tests
were normal, and the fetal heartbeat also appeared as expected after 3 weeks.
But why the Thrombosis test
became abnormal? Our body situation is dynamic. If you are healthy today do not
represent you won't get sick tomorrow.
Think
about why these three teacher pay for sky-high price to learn these before
success in their tough journey.
If you ask me where is the cheapest
place to do IVF? I won't answer! Because there's always a cheaper place.
But if you change the question to
"How to bring a healthy baby back home with the least hardship and most Cost-effective?'' I'll answer you without any
doubt-- 3+ IVF! Because you can get 80% of successful rate with only one embryo
transfer. We design your own personal precisely IVF treatment and every step is
based on evidence. After failed
unfortunately, we can also check from the very end to see is there any possible
factors that become the "murder". Different from traditional IVF,
using your own body to do "experiments".
Want to meet you so bad! Stork
Fertility Center likes to choose a challenging path! This year is our 20th anniversary.
We open a special appointment "Reimplantation Failure appointment".
Please don't come if you like to chat or heard that Dr. Lai is not patient to
clients. But for those who already traveled around the world and are longing to
become parents as soon as possible, please come to join this journey. It's better that you believe in
"precise treatment", knowing that everything happens for a reason and
believing that you will only success when you are on the right track!
Register：Oversea Form
Facebook：e-Stork FB Page
E-mail：en_service@icryobank.comWhatsApp：+886-905-737-501
Do you have the experience of repeated
implantation failure in IVF program? Or even though after pregnancy, still
undergo miscarriage or fetal demise? In these situation, the most important thing
to do is try to find out what factor is the "murder" of your child.
What's the most sorrow thing on the journey to get a baby?
Taiwanese celebrity汪用和 use fourteen years trying to get a baby. The other celebrity黃光芹 said "The hardship on the journey for getting a baby is like dying for several times ." They both decide to adopt a child in the end. And there are still a lot of people keep going on this journey. Such as super model 林志玲, celebrity 張秀卿 and the one who read this article without giving up. How can we do for next step to get to the happy ending?
Want to meet you so bad! It's OK that
if you have a meeting with others but they cancel it at the very end. You can
just rearrange it. However, what will you feel if they disappeared without
saying why?
Friends that break their promise do not worth profound friendship. And what if this happen on your journey of getting a baby? Is it trustworthy to use the same treatment after repeated implantation failure without knowing the reason of failure?
Changing to another scenario. Getting pregnant every time after implantation but every fetus couldn't keep growing then get abortion is already miserable enough. When hearing a physician say "let's try harder next time" what will you feel? How can you bare this twice or even three times in a row?
If you run on the wrong road, you will never reach the end.
When you fail after two implantation or getting abortion twice in a row. It means "the murder" is still there. The most important thing to do at this point is to stop the pace and try to find out "the murder".
Everything happened for a reason. I always believe that you must have done something right to lead to success. In other hand, there might be something wrong lead to failure. If we find out the factor precisely and exclude it in next treatment, there's no reason that we will fail next time.
Clients are our teacher. That's also why I like to use real stories to share with others. Following I'll take three clients that left our center with smile of success for example.
39 years old Mrs. A
When A came to our center for the first time, she already underwent two times of implantation failure. First time was IVF with preimplantation genetic screening(PGS). After failure, doctor suspect that window of implantation is not right. Therefore, she underwent Endometrial Receptivity Analysis(ERA). It turns out that she needs to take progesterone for one more day to get right implantation window.
For the second implantation, with the right time and prevention Heparin injection. She got pregnant successfully. However, the fetal heat beat stopped when it was 8 weeks. She remembered clearly that after first and second implantation, she got bleeding for both time. The blood test of autoimmune and Thrombosis were normal. Therefore, doctor declined the dosage of Heparin from two days a time to three days a time. Meanwhile add progesterone injections. Sadly, the baby is still gone.
The most painful fact is not miscarriage, but not knowing "who killed
my child?''
· We restarted the oocyte retrieval again, but there were no chromosomally normal embryos. Can mosaicism(embryos have both normal and abnormal cells) embryo be an option of implantation? How can we success with two-third of embryo chromosome abnormal rate at her age? With my own experience, if there is bleeding situation after implantation and before pregnancy test, it might because of Thrombus problem. We rechecked related blood tests and as expected they were weakly-positive. Therefore, we adjusted Heparin dosage to one time a day. Today, she is pregnant for14 weeks and 3 days. After hearing the heartbeat, it's time to say goodbye. Finally, She can be transferred to Obstetrician.
45 years old Mrs. B
Before Mrs. B came to our center, she already underwent three times of both oocyte retrieval and transfer. Fresh embryo transfer for the first two times and frozen embryo transfer for the third time. It's a pity that the embryos were all only cultured to day 3 early embryos. Which makes it hard to analyze the possible reason for failure. She was 44 years-old when she came to our center. Oocyte donation program should be a better choice for her. However, she rejected and choose to use her own eggs. She collected four embryos that was not proper to do biopsy and then transferred for the fourth time. She also did ERA before her transfer. However, she failed again.
Then she changed her mind to do donor program, to try for her fifth time. After transferred one chromosomally normal embryo, with ERA test, she still failed. Were there still other "murders" out there?
We checked all her autoimmune and Thrombosis blood tests again. And found out her Nephelometry IgG result was higher than reference. The only difference between sixth transfer and fifth transfer is that we gave her Intravenous immunoglobulin(IVIG) injection three days before transfer. And started heparin injection one time a day from her transfer date. Now, she is pregnant for eleven weeks and one day. We are so happy for her.
45 years old Mrs. C
Before Mrs. C came to our center, she already failed for three times. She wouldn't want to try traditional IVF. Before our suggestion, she decided to do 3+ IVF( with PGS and ERA). She got pregnant after first transfer. Although she had some bleeding during her eighth week but baby heartbeat was normal at that time. With normal Thrombosis blood tests, progesterone injections and pills. When she came back after two weeks, the fetus is still growing. However, the fetus stopped growing next week unexpectedly. It was a real bolt from the blue that made her heart broke. Isn't it comparably safe after 10 weeks? Moreover, it is 3+ IVF this time!
My detective instinct told me it might be Thrombosis problem due to the bleeding situation after transfer. Therefore, I added two blood tests to be monitored this time. All tests were normal on the pregnancy test date. And there were no bleeding situation before fetal heartbeat check. We checked Thrombosis blood test for one more time and accidently found that one of the test became to abnormal. We immediately increased the dosage of heparin form two days a time to everyday. Now she is pregnant for eleven weeks and four days. Congratulations to her for finally finding the hiding murder and say goodbye to those misery days after failure.
Clients
are our teacher
Mrs. A gave us two lessons.
First lesson- please don't ask "should I do ERA test?" anymore.
Second lesson- If there are bleeding situation during pregnancy, please beware that Thrombosis might be killing your child. Don't just think of taking progesterone injections.
Mrs. B also gave us two lessons.
First lesson- Over 43 years-old should choose oocyte donation program directly. Don't waste money.
Second lesson-Infertility doctors should accept humbly that there are some people who have immune system problems that will lead to the system attacking embryos causing reimplantation failure.
Mrs.
C gave us two lessons that's more valuable.
First lesson- follow only one Thrombosis test is not enough. It is more accurate to test two at the same time.
Second lesson- Today's result is not able to represent tomorrow's. The data of two Thrombosis tests were normal, and the fetal heartbeat also appeared as expected after 3 weeks. But why the Thrombosis test became abnormal? Our body situation is dynamic. If you are healthy today do not represent you won't get sick tomorrow.
Think about why these three teacher pay for sky-high price to learn these before success in their tough journey.
If you ask me where is the cheapest place to do IVF? I won't answer! Because there's always a cheaper place.
But if you change the question to "How to bring a healthy baby back home with the least hardship and most Cost-effective?'' I'll answer you without any doubt-- 3+ IVF! Because you can get 80% of successful rate with only one embryo transfer. We design your own personal precisely IVF treatment and every step is based on evidence. After failed unfortunately, we can also check from the very end to see is there any possible factors that become the "murder". Different from traditional IVF, using your own body to do "experiments".
Want to meet you so bad! Stork
Fertility Center likes to choose a challenging path! This year is our 20th anniversary.
We open a special appointment "Reimplantation Failure appointment".
Please don't come if you like to chat or heard that Dr. Lai is not patient to
clients. But for those who already traveled around the world and are longing to
become parents as soon as possible, please come to join this journey. It's better that you believe in
"precise treatment", knowing that everything happens for a reason and
believing that you will only success when you are on the right track!
Register：Oversea Form
Facebook：e-Stork FB Page
E-mail：en_service@icryobank.comWhatsApp：+886-905-737-501
Advance examinations for IVF at 2020
8/31/2020 12:32:00 AM
EMMA and ALICE
What is EMMA (Endometrial Microbiome Metagenomic Analysis)?
The test is aimed to analyse the endometrial microbiome to help identify abnormalities associated with a poor reproductive prognosis.
EMMA is a molecular tool used to determine whether the uterine microbial environment is optimal for endometrial health. This molecular method is based on detecting and measuring the amount of bacterial DNA present in the endometrial sample.
Therefore, EMMA helps to determine when the endometrium presents a physiological bacterial flora. Lactobacilli accounts for less than 90% of the microbiotal in the endometrium which will lead to significantly decrease in pregnancy rate.
If the result comes back indicated “ ABNORMAL ENDOMETRIAL MICROBIOME” , doctors can provide appropriate probiotics suggested by the report for the patient to use in order to create a better endometrium environment for later implantation.
Why use EMMA test?
EMMA uses the latest Next Generation Sequencing (NGS) technology to provide endometrial microbiome information by analysing the complete profile of the bacteria present in the tissue
EMMA can determine the percentage of Lactobacillus present in the endometrium; low proportions of Lactobacillus are associated with lower pregnancy rate.
EMMA includes the ALICE test, so it indicates the possible presence of bacteria that can cause chronic endometritis, further other pathogenic bacteria.
If the endometrium is non-Lactobacillus dominated, the report will suggest the adequate treatment for each patient
EMMA will determine whether the uterine microbial environment is optimal or not for embryo implantation
Who should use the EMMA?
Patients with repeated implantation failure (RIF)
EMMA can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation
How is EMMA done?
Doctors will use pipelle endometrial suction curette to go into the uterus through vagina, acquire a small amount of endometrium samples. The whole procedure takes around 30 seconds to 1 minute.
What is ALICE (Analysis of Infectious Chronic Endometritis)?
Chronic endometritis(CE)will lead to endometritis which is one of the reasons for infertility and under most circumstances patients do not appear with obvious symptoms.ALICE is a test that detects pathogenic bacteria and recommends adequate treatment. In traditional IVF, doctors can not diagnose the bacterias specifically, and can not prescribe the appropriate treatment.
ALICE is a diagnostic test to detect and quantify the most common 8 pathogenic bacteria causing chronic endometritis, recommending appropriate antibiotic and probiotic treatment
-Enterobacteria (e.g. Escherichia, Klebsiella)
-Chlamydia
-Mycoplasma
-Neisseria
-Ureaplasma
-Enterococcus
-Streptococcus
-Staphylococcus
※ In cases of repeated implantation failure or recurrent pregnancy loss, chronic endometritis can rise to 66%.
Who should use ALICE?
ALICE can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation.
ALICE may also be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.
How is ALICE done?
Contorl you feutre, Beyond Eggs and IVF 3.0+ plus
8/31/2019 08:52:00 AM
she didn't want to fly over for ERA, so we transfer 1 normal embryo with the traditional format. Unfortunately, we failed. She did ERA at the next month, found that.....
Can we control our future ? What if we can make plans for our life, what will your future like?
Miss F from Nanjing, China, had followed her plan of life, came to Stork at the age of 32, with a high AMH data, 3.81ng/ml. Been through 2 oocyte-pick up surgery, froze and stored 25 mature eggs.
Two years later, Miss F meet her Mr.Right and got married. Tried to have a baby for a year but life is not what she expected. Did a test of her AMH again, only 0.8 left. At age 35, she thawed the eggs started IVF treatment. 20 out 25 mature eggs survived, after insemination, culture for 6 days, we created 9 embryos, and 5 of them graded 5BB and the other 4 were BC grade. Implantation fails or success, it really depends on whether the chromosome is normal or not, even if the gradings are good.
Embryo gradings are just for reference, Miss F choose to do IVF 3.0+, 5 BB grading embryos were all biopsied and 3 of them sent for PGS test. Two out of three are with normal chromosome, one is with partial abnormalities. With younger age group comes with lower chromosome abnormalities, she is very lucky that she had chosen to freeze eggs at a young age. According to statistics, the embryos that created by the 32-year-old group can have almost 60% normal chromosome rate. These 3 embryos are suitable for implantation, form our experience, transfer 1 embryo with normal chromosome can achieve 60~70% pregnancy rate.
As Miss F lives overseas, she didn't want to fly over for ERA, so we transfer 1 normal embryo with the traditional format. Unfortunately, we failed. She did ERA at the next month, found that the WOI(window of implantation) is different than others, intake progesterone for 96 hours, which is 24hours earlier than our traditional format, that might be the main reason why we failed the first time.
Two months later, Miss F took progesterone for 96 hours and with a normal embryo, we performed precise implantation. After two weeks, her ßHCG data reached 10,567! Three more weeks later, we have a heartbeat. She is now a happy mother-to-be.
What were the factors of a perfect ending? the answer is ’IVF 3.0+’. Without PGS, how can we know whether the embryos are normal or not? Without ERA how can we know the precise WOI for each one? It is a huge waste if we transfer a normal embryo at the wrong time. Also if we are at the right time transferring an untested embryo, is just gambling. Is not like we can depend on appearance only. With PP-IVF ( personalized precision IVF), we can make it work.
Life is full of uncertainty, we can not control our future, but we can freeze our eggs for our future. About egg freezing, some might not understand how it works or near heard of it, worrying about it is not useable in the future, or the thaw-egg pregnancy rate. Afraid of missing put the optimal age to conceive a child, at the age 35-37, the cost-performance ratio is the best. It is proofed by science, after age 38, the quality of egg drop rapidly, which made the coat of doing IVF a lot higher compared to use frozen egg at age 35-37.
Stork’s oocyte bank use thawed egg for egg recipients’ IVF treatment, at 2018, we thawed 7,604 eggs and 7,206 survived. The survival rate achieved by 95%. The following fertilization rate 77%, embryo rate 66%. It's much likely equal to fresh eggs. determine the technology level is not only by the freeze-thaw result. Appling polarized microscope to do insemination at the right time is also very important. As well as the embryo culture system, and can it apply PGS to determine whether the embryo is normal? If the answers are all YES, then transfer 1 normal embryo can reach 80% pregnancy rate. This is the most important criterion to choose to freeze " Beyond Egg". It is only worth it if we can use the Beyond egg to create the highest pregnancy rate!
What! In-vitro fertilization with 1 embryo transfer can reach 80% pregnancy rate!
4/30/2019 05:07:00 AM
Register：Oversea FormEgg donation - The Giver and the Taker
2/27/2019 01:06:00 AM
Egg donation - The Giver and the Taker
There are some women are infertile due to the ovulation function failure, common reason include congenital under-developed ovary( e.g Tunner syndrome) ; premature ovarian failure (e.g due to infection, surgery, immune system or medication treatment, cause the premature ovarian failure). And some women are carrier of chromosome disease, for example hemophilia, using donated Egg can really help to slove the problems.
- Where are the
Egg come from ?
Most
girl donating oocytes aim to help people, few of them are patients doing IVF,
end up getting more oocytes that she need, so donation can be an option. Miss Y
was doing IVF, but because of she suffered from Polycystic Ovary Syndrome(PCOS), end up getting more than 20 oocytes,
more than she needed.So she froze the rest and donated to others.
- Privacy
According
to the Taiwan governments’ Assisted Reproduction Act, “Assisted reproduction
institutions shall not provide reproductive cells donated by a single donor to
two or more recipient couples at the same time” Personal information of the
donor and the recipient shall remain confidential, we can only provide donor’s
health condition, heigh, weight, blood type, skin color.. mainly objective
description to recipient couples for reference.
- donor `s criteria
women at least 20 and less than 40 years of age,
has never donated Egg before.
- the heath Evaluation
Other
than hereditary disease from the family and chromosomal abnormality , history of epilepsy and
hemophilia, we do blood test on infectious diseases, such as mediterranean
anemia, diabetes, hepatitis B, gonorrhea, syphilis, AIDS, etc.
- what do the
donor need to prepare
After
passing the blood test and checking the qualification with the government,
donor can start treatment from menstruation cycle day 3, using medication for
around 10 days, egg are becoming more mature. Throughout the procedure, we
monitor the growth of egg using ultrasound and blood tests. Around cycle
day 14, egg-pick-up surgery will be arranged, under anesthesia. The surgery
last 10-15 mins, after 1-2 hours rest, treatment is completed.
- Side effects
of egg donation
- What do the
recipient need to prepare
the endometriumis smooth and no Edema at both fallopian tube. Then will start medication at day 5 of your cycle. Prepare the best environment for embryo to bed.
- Will my kid
look like me?
There are half gene of the kid are from the father, half are from the donor. As for
the matching process, the priority will be the blood type. Then we will
according the criteria that you make for the donor, try out best to find a
perfect donor for you.
- Can egg be frozen?
Positive. Vitrification is a common use technology at crypreservaion of oocytes and embryos. Vitrification is a cryopreservation technique that leads to a glass-like solidification. Oocyte, embryo and blastocyst freezing by vitrification method for cryopreservation have been used for many years beside sperms preservation. Moreover, the use of vitrification technology for ovarian tissue cryopreservation to freeze eggs offers such an elderly women who sometime find more difficulty in conceiving or in maintaining pregnancy till full term because of old age compared to relatively younger women who might get better chances to get a healthy pregnancy. Furthermore, vitrification helps cancer patients who are looking to preserve their fertility later on after completing their treatment.Assisted Reproduction Act issued by Taiwan Ministry of Health and Welfare
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WhatsApp：+886-905-737-501Quality and quantity , Guide for transferring blastocysts
10/29/2018 12:28:00 AM
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"The doctor told me that transferring 2-3 blastocysts are good enough, but my husband wants to do all 4 that all we have, as the previous 3 went through PGS were abnormal..." When I got your call, I can feel your worries, hopeless, hesitating, wanting to talk to someone.
one is the success rate of IVF, the other one is chances of having multiple births, how can we find the balance? From the perspective of modern artificial reproductive, the goal is to bring a healthy baby back home asap.
Multi-pregnancy pregnancy bears high risks for the mother and the baby as well, including premature birth, gestational diabetes, pre-eclampsia, fetal underweight, etc., and there are risks in fetal reduction surgery.
To maintain the success rate of artificial reproduction and reduce the risk of multiple births, countries have begun to set guidelines for the fertility centers, suggesting the number of blastocysts for implantation.
How many should we transfer? How can we provide the most substantial help?
European countries set a guideline for themselves considering the number of implants, blastocysts grading, age, and other parameters.
According to the Taiwanese Society for Reproductive Medicine (TSRM), the suggested number of blastocysts for implantation are as follow. For blastocysts with normal PGS result, transferring one will be enough.
Strok Fertility Center collected the four-year data from 2013.-2017.01, there were 2,857 thawed blastocysts implantation cycles, which were divided into five age groups according to the TSRM index. The average number of implants was 1.65 vs. 1.82 vs. 1.97. Vs. 1.98 vs.1.00; and multiple birth rates were 16.1% vs. 15.2% vs. 9.9% vs. 4.7% vs. 0.3%.
We measured the live birth rate data from the period of 2013.01-2015.12. There were 1,842 thawing implantation cycles, and the average number of implantation is 1.70 vs. 1.80 vs. 2.01 vs. 1.96 vs. 1.00. As for the live birth rate was 52.9% vs. 48.8% vs. 33.6% vs. 17.5% vs. 43.0%.
"Transferring a normal blastocyst, giving you a healthy baby" has always been our biggest goal. As we mentioned at the beginning, the client was facing a predicament that all the blastocysts were abnormal and cannot be implanted.
Although she was 37 years old and the prevalence rate of embryo abnormality is high, I still did not recommend that she transfer all the rest four unexamined blastocysts.
After listening to my analysis of the pros and cons, she thanked me happily. It seemed to help the client to clear her thoughts. I believe that no matter what the final decision is, she will be okay.
Reference:
1.Clinical data by Stork Fertility Center
2.TSRM guideline (2016）
Andi's word
1. The abnormal rate of the 37-year-old group woman is about 46.2% based on the PGS(preimplantation chromosome screenings) test of 2,980 of blastocysts. However, according to the study of the relationship between
the result of transfer a single embryo with normal chromosome and the grading of blastocysts that published by our center in 2017, not every blastocyst is suitable for PGS, and the blastocyst with poor grades are more vulnerable even if the test results show that the chromosomes are normal. Result in a lower pregnancy rate.
2. The Taiwanese Society for Reproductive Medicine (TSRM) introduced a guideline based on the "maternal age", "with or without chromosome screening" considering the clinical data of local fertility institutions.
the success rate of transferring a blastocyst with normal chromosomes is about 60%, but it is true that not every blastocyst is suitable for biopsy and examination. As the way of cultivation might be different at each different institution (eg. splinter culture vs blastocyst stage culture), blastocyst parameters are different (pollardization time, appearance grading), different personal experiences (implanted several times, maternal environment), it is not the best way to apply one single fixed formula to each case.
The primary purpose of Personalized Precision(PP-IVF) is to provide tailor-made medical assistance that best meets the needs of the individual.
We have to keep a balance of the pregnancy rate and the risks of multi-birth.
Other than adjusting the number of blastocysts for implantation, "immune system screening", " hysterosalpingogram (HSG) ", " Hysteroscopy ", and "ERA (Endometrial Receptivity Array)” etc. are also factor that might affect the bedding. We no longer just transfer with few blastocysts, we transfer the right one at the right time in the right place!
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