Showing posts with label Embryo transfer. Show all posts
Showing posts with label Embryo transfer. Show all posts
The Key for Implantation - Endometrium Thickness
12/26/2018 12:25:00 AM
The Key for Implantation - Endometrium Thickness
Stork Fertility Center
Dr. Lee
In IVF, we’ve been discussing the ideal thickness of endometrium for implantation.
Besides, is the criteria the same for both fresh blastocysts and frozen-thaw blastocysts implantation? Will it be the same? We did not have many studies on the above issue.
This September(2018), Human Reproduction, a research team from Canada, using the database of local IVF treatment, analyzed over 40 thousand implantation cycles of both fresh blastocysts transfer(BT) and frozen-thaw blastocysts transfer (FBT).
A result had been found: Clinical pregnancy and live birth rates decline as the endometrial thickness decreases below 8 mm in BT and below 7 mm in FBT cycles.
As shown in the study,in the BT cycle, the pregnancy rate for endometrium thickness ≥8mm is 43.2%, the abortion rate is 22%, the live birth rate is 33.7%. Comparing to the statistics of thickness.
In FBT, the pregnancy rate of endometrium thickness≥7mm is 38.3%~38.4%, the abortion rate is 26~28.4%, the live birth rate is 27.4~28.4%. Comparing to the statistics of thickness.
To conclude, the indicator of endometrium thickness for implantation are as following:
Fresh blastocysts transfer: ≥8mm
Frozen-thaw blastocysts transfer: ≥7mm
With a good uterus environment, comes with a better clinical outcome. Good things are worth waiting for.
REF:
Hum Reprod. 2018 Sep 17. The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: ananalysis of over 40 000 embryo transfers. Liu KE, Hartman M, Hartman A, Luo ZC, Mahutte N.
IVF Journey x Blastocyst Accumulation
8/27/2018 07:39:00 PM
Several studies have shown maternal age as a determining factor in IVF treatment.
Most of our patient are suffered from diminished ovarian reserve and/or advanced maternal age. For women over 38-year-old, with declined ovarian reserve, accumulating blastocysts is the strategy we use. Both the quality and quantity of oocytes are adversely affected by the age. They may experience repeated IVF failure caused by few or no embryos to transfer. In this cohort, accumulating blastocysts could be used to increase the chance of pregnancy.
What is oocytes accumulation? What is blastocysts accumulation?
Oocytes accumulation aimed at collecting oocytes, and freeze it. After we had collected enough oocytes, we thaw all oocytes and fertilize and culture them in one batch.
Blastocysts accumulation aimed at creating blastocysts and freeze it. After each oocyte retrieval surgery, we fertilize the eggs and culture till day 5~6 then freeze it.
The clinical outcomes of different age using different treatment shown.
But the pregnancy rate of oocytes or blastocyst accumulation did not show a significant difference.
To conclude, for age under 38y/o, the pregnancy rate can be reached around 50~70% regardless of what treatment is used; however, forage over 38y/o, the pregnancy rate will be double using blastocyst instead of oocyte
the pregnancy rate of age over 38y/o is nearly double that of the ovulation pregnancy rate.
How many blastocysts should I collect?
Without pre-implantation genetic screening(PGS), the basis for embryo implantation can only be judged by the developmental speed and appearance level.
Therefore, the pregnancy rate and live birth rate vary with age.
The estimated fee for both treatments is as follow.
To increase the pregnancy rate and live birth rate furthermore, we introduce you the Third generation IVF Plus( PGS + ERA) . For further require, please contact us
Leave a message down below, we are more than willing to answer!
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WhatsApp：+886-905-737-501[Patient Testimonial] Never give up for having a baby-Oocyte Donation Program
5/31/2018 09:37:00 PM
Faith
means believing the unbelievable.
When we are the freshmen of Stork Fertility Center, we have the training program.
One of the course is that we need to entering the examination room, listening doctor's treatment and how to communicate with patients in order to make our advisory smoothly. When the patients tell their own story about the desire of having baby, we more understand what they have been through, and how they want this treatment bring result as expectation. That's why each movement we do is assigned a responsibility. Moreover, this follow-up process will strengthen the establishment of empathy and the special emotional connection with patients.
One of the course is that we need to entering the examination room, listening doctor's treatment and how to communicate with patients in order to make our advisory smoothly. When the patients tell their own story about the desire of having baby, we more understand what they have been through, and how they want this treatment bring result as expectation. That's why each movement we do is assigned a responsibility. Moreover, this follow-up process will strengthen the establishment of empathy and the special emotional connection with patients.
One of my training
program, there is one couple makes me impressive.
"Did you use the
pregnancy test kit at home?" doctor asked. I think that doctor try to make
examine room more relax to ask this question. The husband said " No, we
are too nervous to test by ourselves." And the wife didn't say anything
next to husband. As the doctor open and show that pregnancy strip test, ask the
couple "Could you recognize the second line on the test kit?"
Suddenly, the husband popped up and said " I knew it. I pray to God last
night, and ask the priest. See! Look at my Line message. He told me so in this
message." Compared with silence wife, husband looked to excited. They
pray, pray a lot, pray sincerely. I could see their joy in their eyes. However,
that's my first time and the only one to meet this joyful couple. And I kept
the wife's name in my note.
In this electronic and internet generation, people could make
friends without face-to-face. Reading all the medical record of this couple, it
could tell why they come to Stork fertility center and how hard and serious
they try to have the baby. After reading the paper of medical record, I think I
become more familiar with them.
They began the treatment in Stork fertility center in 2015. After some examination, we are quite sure that tubal and uterus are no problem. However, due to their ages, they registered for oocyte donation program. we matched a young and appropriate donor soon, and we got total 12 mature eggs for this time. The donor gave us 19 mature eggs, and eight blastocysts derived. Two embryos were thawed, and they were graded as 4BB and 4BA. They would have started the first course of treatment, but due to the wife’s persistent bleeding, they decided to cancel after discussion with the doctor. They started the second treatment with transfer a 4BA embryo, but still haven't good news yet.
However, due to the last embryo, the couple were worried about if they still don't have the good news with second transfer, they will spent more time to match another oocyte donor. So we spent a little time to have second match. Soon and later, we got 10 mature embryos. In the same time, second transfer have been finished, and they still don't get the result they want.
Faith, is all around the world. Seeing this couple even face some difficulties, but they haven't been defeated. I will share this story to my customers, and tell them "Faith means believing the unbelievable."
Stork fertility center hold the "Annual Stork Party" every year. The
purpose of this dinner is to invite the parents bring their IVF baby by Stork.
They could share the joy with doctor, and let we could how big babies are. Due
to we see all these babies from egg to embryo, and now they are sweet babies.
Also the parents could share some different life experience with baby. What's
more, the party could remind us the original intention of work "Sweet
baby, Sweet home".
Remember, please come
back to our Annual Stork Party after you graduate from this long journey.
Faith, is all around the world. Seeing this couple even face some difficulties, but they haven't been defeated. I will share this story to my customers, and tell them "Faith means believing the unbelievable."
Register：Oversea Form
Facebook：e-Stork FB Page E-mail：en_service@icryobank.com WhatsApp：+886-905-737-501
Register：Oversea Form Facebook：e-Stork FB Page E-mail：en_service@icryobank.com WhatsApp：+886-905-737-501ERA program (ERA procedures)
3/22/2017 09:04:00 PM
One step to start a family--
When to eat progesterone, transfer...and more!
IGENOMIX, a leading team of reproductive genetics in Spain, has developed ERA to analyze the gene expression of endometrial tissue. This method helps us determine if the endometrium presents the ideal condition for implantation of embryo (WOI, window of implantation), and thus pregnancy rate would be improved.
To know more about ERA: http://taiwanivfsfc.blogspot.tw/2017/02/endometrial-receptivity-array-era.html
Endometrial Receptivity Array (ERA)
2/20/2017 11:39:00 PM
Have you ever heard the phrase of personalized precision IVF?
Nowadays, the individualized medicine is more prevalent.
With the improvements in ART,
some patients still suffer by repeated implantation failure.
Why?
It's time to think about "personalized embryo transfer (pET)."
Embryo implantation is a highly complex process incorporating with a healthy embryo, a receptive endometrium, and a molecularly communicative dialogue in between. Until 2016, Stork Fertility Center has comprehensive applied individualized COS, IMSI/ICSI, blastocyst culture, PGS/PGD, donor gametes, and frozen embryo transfer for the cases with specific indications. Moreover, all patients would be requested to take the hysteroscopy, hysterosalpingograrphy, and cervical bacteria culture before entering the transfer cycle. However, still some patients failed after couple of transfers.
Should I do surgery for cyst removal?
2/12/2014 11:52:00 PM
Different sequential changes due to different mechanisms cuasing damage to the ovarian reserve
Menstrual pain, painful intercourse, and frequently lower abdominal pain are not unfamiliar to the women who are suffering with endometriosis. Besides this annoying pains, the problem of infertility is another agony. Endometriosis is one of primary infertility causes, especially if one or both ovaries are involved, and ovarian endometriomas are found in 20% of patients with endometriosis. The most common symptoms is so called as chocolate cyst, which is built up by menstrual blood over months and years and turned to brown color.
Ruptures of ovarian endometrioma are associated with pelvic adhesion and infections, so many patients would like to remove the cyst to alleviate pelvic pain or improve spontaneous fertility. However, the most effective treatment modality to endometrioma is still controversial. The postoperative safety to the ovarian function and the recurrence of the disease are two unsolved problems. In the published article of Fertility and Sterility Journal (2013), the group in department of obstetrics and gynecology, Nagoya university, has reported the statistical data of the endometrioma patients undertaking cystectomy. They analyzed the AMH levels of these patients before and after the surgery to evaluate the effect. The patients with bilateral cystectomy showed significant reduced AMH than that of patients with unilateral cystectomy,
AMH (ng/ml)a
|
Unilateral
|
Bilateral
|
P-valueb
|
Preoperative
|
4.21
|
3.49
|
0.944
|
Postoperative one month
|
2.49
|
1.04
|
0.03*
|
Postoperative one year
|
2.72
|
0.9
|
0.92
|
b P-value < .05, statistic difference