Career first, children later: Taiwan women put their eggs on ice
8/29/2013 12:30:00 AM
HSINCHU, Taiwan | Tue Aug 27, 2013 10:44am IST
(Reuters) - Caught between traditional expectations and career pressures, working women in Taiwan are increasingly opting to freeze their eggs at fertility clinics as they postpone marriage and motherhood.
Women play a big part in Taiwan 's
workforce, trailing only New Zealand
and Australia for female
employment among 14 countries in Asia , a
recent report by MasterCard showed.
Experience of blastocyst culture in dry culture system
8/08/2013 12:47:00 AM
Experience of blastocyst culture in dry culture system
| Author | Hsing-Hua Lai*, Huai-Ling Wang, Wen-Yi Chiang, Yao-Cheng Huang, Saing-Chi Chen, Wan-Jung Hsieh, Chun-Chuan Chen, Chi-An Hsieh, Shih-Chieh Huang, Ya-Hui Hsu, Hsin-Hua Chou |
|---|---|
| Editor | |
| Seminar name | |
| Keyword | |
| PDF download |
The advantages of dry culture system include minimal risk of contamination, fast recovery of gas concentration, and more stable temperature controlling. From economical point of view, dry incubators are space and gas saving due to small chamber volume. However, there are disadvantages such as swift variation of environment and higher water evaporation rate. Dry incubators are not as common as humidified incubators in routine use. To assess the clinical application, a preliminary feasibility study was conducted.
Accumulating oocytes or blastocyst for low responders? Age as a criterion
8/08/2013 12:46:00 AM
Accumulating Oocytes or Blastocysts for Low Responders? Age as a Criterion
| Author | Shih-Chieh Huang, Huai-Ling Wang, Wen-Yi Jiang, Hsing-Hua Chou, Hsing-Hua Lai |
|---|---|
| Editor | Hsing-Hua Chou |
| Seminar name | 2012Asia Pacific Initiative on Reproduction |
| Keyword | Blastocyst vitrification, oocyte vitrification, DOR |
| PDF download |
Low responders (LRs) are mostly from diminished ovarian reserve and/or advanced maternal age. They may experience repeated IVF failure caused by few or no embryos to transfer. In this cohort, accumulating oocytes or blastocysts to obtain more embryos could be benefit in improving clinical pregnancy rate (CPR). Several studies have shown maternal age as a determining factor in IVF treatment. In this study, we compared IVF outcome between two groups with oocyte or blastocyst accumulation at different age levels.
Blastocyst stage microarray-based genomic screening in improving clinical pregnancy rate and implantation rate
8/08/2013 12:45:00 AM
Blastocyst stage microarray-based genomic screening in improving clinical pregnancy rate and implantation rate
| Author | Hsing-Hua Lai, Huai-Ling Wang, Wen-Yi Chiang, Shih-Chieh Huang, Ya-Hui Hsu |
|---|---|
| Editor | Shih-Chieh Huang |
| Seminar name | 2011 TSRM |
| Keyword | PGS, aCGH, blastocyst culture |
| PDF download |
Identification of embryos with the highest implantation potential is a crucial step in IVF. Blastocyst transfer (BT) has been proved to have higher implantation rate and live birth rate than D3 embryo transfer owing to a further embryo selection mechanism. However, morphological grading provides us only part of clue to choosing a best quality blastocyst. As chromosome abnormality plays a role in pregnancy failure for woman of advanced maternal age and repeated implantation failure, it is important to evaluate the chromosome status before BT to reduce miscarriage rate.
Comparison of the embryo development and clinical pregnancy rates between vitrified and fresh oocytes
8/08/2013 12:43:00 AM
Comparison of the embryo development and clinical pregnancy rates between vitrified and fresh oocytes
| Author | Hsing-Hua Lai, Huai-Ling Wang, Wen-Yi Chiang, Yao-Cheng Huang, Saing-Chi Chen, Wan-Jung Hsieh, Chun-Chuan Chen, Chi-An Hsieh, Shih-Chieh Huang, Ya-Hui Hsu, Hsin-Hua Chou |
|---|---|
| Editor | Shih-Chieh Huang |
| Seminar name | 2012 TSRM |
| Keyword | vitrification, cryo-oocyte, pregnancy rate |
| PDF download |
In recent years, oocyte cryopreservation is mainly performed before oncological treatment, but rarely for infertile cause. For non-oncological purpose, such as single women with advanced age, autoimmune disorders, or for couples with male infertility, oocyte vitrification could retain the possibility of future utilization.
To assess the clinical practicality, we compared vitrified and fresh oocytes in their embryo development and pregnancy rates with our clinical data.
Comparison of the obstetric outcome between fresh and vitrified-warmed blastocyst transfer
8/08/2013 12:40:00 AM
Comparison of the obstetric outcome between fresh and vitrified-warmed blastocyst transfer
| Author | Hsing-Hua Lai, Huai-Ling Wang, Wen-Yi Chiang, Shih-Chieh Huang, Ya-Hui Hsu |
|---|---|
| Editor | Ya-Pei Pong |
| Seminar name | 2011 22th AOCOG |
| Keyword | vitrification, blastocyst culture, pregnancy rate, live birth rate |
| PDF download |
Objectives
To evaluate the effects of vitrification and embryo development on
implantation rate, clinical and ongoing pregnancy rates along with live birth
rate.
Methods
- A randomized, retrospective
study
- Fresh and vitrified-warmed
blastocyst transfer (BT)
- Statistical methods: Student t
test and Yate’s continuity corrected χ-square
- Definition:
- Biochemical pregnancy: blood β-hCG > 5mIU/mL
- Clinical pregnancy: gestational
sac observed under ultrasound at 6-8 weeks of pregnancy
- Ongoing pregnancy: pregnant
after 5 months
- Implantation rate: gestational
sac or fetal heart beat (FHB) per transferred embryo
Conclusions
Our
preliminary data suggested that:
1.
Vitrification
had no obvious adverse effect on embryos. In fact, it could be beneficial to
increase cumulative pregnancy rate.
First successful pregnancy after preimplantation genetic diagnosis for Hemophilia A in Asia
8/08/2013 12:32:00 AM
First successful pregnancy after preimplantation genetic diagnosis for Haemophilia A in Asia
| Author | Hsing-Hua Lai, Huai-Ling Wang, Shih-Chieh Huang, Wen-Yi Chiang |
|---|---|
| Editor | Hui-Ling Kao |
| Seminar name | 2010 TSRM |
| Keyword | PGD, inherited disease, IVF |
| PDF download |
Haemophilia A, the most common X-linked disorder affecting males, results from deficient or defective coagulation factor VIII which impairs the coagulation cascade (Fig. 1) and causes bleeding symptoms. In Taiwan, there are about 1000 haemophilia patients, where the cost on medication is 2,300 million dollars per year. Different types of factor VIII gene mutation have been characterized and among which, intron 22 inversion is the most seen and responsible for 45% of severe HA cases.
The conventional way for HA patients to have an unaffected child is to play “reproductive roulette” and give up all male babies. Preimplantation genetic diagnosis (PGD) provides an alternative strategy for couples carrying HA to conceive a healthy child without sex selection hence to reduce the mental pressure and medical cost. This technique can be performed on blastomere or trophectoderm cells. The DNA in each cell is analyzed for a specific gene mutation, i.e. factor VIII gene in HA. In recent years, the need of PGD for HA is increasing.