Comparison of the embryo development and clinical pregnancy rates between vitrified and fresh oocytes
8/08/2013 12:43:00 AM
Comparison of the embryo development and clinical pregnancy rates between vitrified and fresh oocytes
| Author | Hsing-Hua Lai, Huai-Ling Wang, Wen-Yi Chiang, Yao-Cheng Huang, Saing-Chi Chen, Wan-Jung Hsieh, Chun-Chuan Chen, Chi-An Hsieh, Shih-Chieh Huang, Ya-Hui Hsu, Hsin-Hua Chou |
|---|---|
| Editor | Shih-Chieh Huang |
| Seminar name | 2012 TSRM |
| Keyword | vitrification, cryo-oocyte, pregnancy rate |
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In recent years, oocyte cryopreservation is mainly performed before oncological treatment, but rarely for infertile cause. For non-oncological purpose, such as single women with advanced age, autoimmune disorders, or for couples with male infertility, oocyte vitrification could retain the possibility of future utilization.
To assess the clinical practicality, we compared vitrified and fresh oocytes in their embryo development and pregnancy rates with our clinical data.
Study design
Patients’ characteristic
| Fresh D3ET | Warmed D3ET | |
|---|---|---|
| Cycle no. | 40 | 24 |
| Average age (y/o) | 36.5 | 35.8 |
| Total MII oocytes used | 288 | 176 |
| Average MII oocytes used per cycle | 7.2 | 7.3 |
| Total embryos transferred | 109 | 63 |
| Average embryos transferred per cycle | 2.7 | 2.6 |
Results
》In warmed D3ET group, oocytes were vitrified for several months to one year. The post-warming survival rate was 88.6%.
》The embryo development and pregnancy rate of both groups were listed in the table and figure below:
| Fresh D3ET | Warmed D3ET | χ2-test | |
|---|---|---|---|
| Fertilization rate | 80.1% | 72.4% | NS (p=0.10) |
| Day3 good embryo rate | 52.2% | 50.8% | NS (p=0.91) |
| Clinical pregnancy rate | 42.5% | 37.5% | NS (p=0.89) |
| Implantation rate | 18.3% | 17.5% | NS (p=0.85) |
As shown in the figure, yellow bar represent warmed D3ET group and orange bar represent fresh D3ET group. No statistical difference between warmed and fresh groups in FR, D3GER, CPR and IR.
Conclusion
Our results showed that the cryo-oocyte treatment is feasible in clinical practice, in consideration of the comparable fertilization and embryo development rates as well as IR and CPR to those of conventional IVF treatment. We suggested that it may be applied for patients with non-oncological purpose.
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ReplyDeleteThanks for sharing such nice information.