Array comparative genomic hybridization analysis（aCGH） is a method designed for a rapid scan on 23 pairs of human chromosomes to determine the small fragment loss or duplicate, and further detect over 100 diseases.


Analysis timing:

1. Adults: 5 c.c. blood sample。
2. Fetus: during Amniocentesis (usually 17~ 20 weeks), taking 10 c.c. Amniotic fluid for analysis.

Accuracy:

aCGH can detect the disease related to small chromosome fragment loss, such as Prader-Willi Syndrome, Cri-du-chat syndrome, Di-George Syndrome, and Williams syndrome, with the accuracy as high as 99％.

Amniocentesis is determining the chromosome abnormal like numbers, shifting, exchange, etc. However, the resolution is limited and the small DNA fragment deficiency or repeat wouldn’t be detected. As small fragment loss may result retarded, slow development or facial feature abnormal, combining amniocentesis and aCGH can provide more assurance of fetus health.