Accumulating oocytes or blastocyst for low responders? Age as a criterion
8/08/2013 12:46:00 AM
Accumulating Oocytes or Blastocysts for Low Responders? Age as a Criterion
| Author | Shih-Chieh Huang, Huai-Ling Wang, Wen-Yi Jiang, Hsing-Hua Chou, Hsing-Hua Lai |
|---|---|
| Editor | Hsing-Hua Chou |
| Seminar name | 2012Asia Pacific Initiative on Reproduction |
| Keyword | Blastocyst vitrification, oocyte vitrification, DOR |
| PDF download |
Low responders (LRs) are mostly from diminished ovarian reserve and/or advanced maternal age. They may experience repeated IVF failure caused by few or no embryos to transfer. In this cohort, accumulating oocytes or blastocysts to obtain more embryos could be benefit in improving clinical pregnancy rate (CPR). Several studies have shown maternal age as a determining factor in IVF treatment. In this study, we compared IVF outcome between two groups with oocyte or blastocyst accumulation at different age levels.
Blastocyst stage microarray-based genomic screening in improving clinical pregnancy rate and implantation rate
8/08/2013 12:45:00 AM
Blastocyst stage microarray-based genomic screening in improving clinical pregnancy rate and implantation rate
| Author | Hsing-Hua Lai, Huai-Ling Wang, Wen-Yi Chiang, Shih-Chieh Huang, Ya-Hui Hsu |
|---|---|
| Editor | Shih-Chieh Huang |
| Seminar name | 2011 TSRM |
| Keyword | PGS, aCGH, blastocyst culture |
| PDF download |
Identification of embryos with the highest implantation potential is a crucial step in IVF. Blastocyst transfer (BT) has been proved to have higher implantation rate and live birth rate than D3 embryo transfer owing to a further embryo selection mechanism. However, morphological grading provides us only part of clue to choosing a best quality blastocyst. As chromosome abnormality plays a role in pregnancy failure for woman of advanced maternal age and repeated implantation failure, it is important to evaluate the chromosome status before BT to reduce miscarriage rate.
Comparison of the embryo development and clinical pregnancy rates between vitrified and fresh oocytes
8/08/2013 12:43:00 AM
Comparison of the embryo development and clinical pregnancy rates between vitrified and fresh oocytes
| Author | Hsing-Hua Lai, Huai-Ling Wang, Wen-Yi Chiang, Yao-Cheng Huang, Saing-Chi Chen, Wan-Jung Hsieh, Chun-Chuan Chen, Chi-An Hsieh, Shih-Chieh Huang, Ya-Hui Hsu, Hsin-Hua Chou |
|---|---|
| Editor | Shih-Chieh Huang |
| Seminar name | 2012 TSRM |
| Keyword | vitrification, cryo-oocyte, pregnancy rate |
| PDF download |
In recent years, oocyte cryopreservation is mainly performed before oncological treatment, but rarely for infertile cause. For non-oncological purpose, such as single women with advanced age, autoimmune disorders, or for couples with male infertility, oocyte vitrification could retain the possibility of future utilization.
To assess the clinical practicality, we compared vitrified and fresh oocytes in their embryo development and pregnancy rates with our clinical data.
Comparison of the obstetric outcome between fresh and vitrified-warmed blastocyst transfer
8/08/2013 12:40:00 AM
Comparison of the obstetric outcome between fresh and vitrified-warmed blastocyst transfer
| Author | Hsing-Hua Lai, Huai-Ling Wang, Wen-Yi Chiang, Shih-Chieh Huang, Ya-Hui Hsu |
|---|---|
| Editor | Ya-Pei Pong |
| Seminar name | 2011 22th AOCOG |
| Keyword | vitrification, blastocyst culture, pregnancy rate, live birth rate |
| PDF download |
Objectives
To evaluate the effects of vitrification and embryo development on
implantation rate, clinical and ongoing pregnancy rates along with live birth
rate.
Methods
- A randomized, retrospective
study
- Fresh and vitrified-warmed
blastocyst transfer (BT)
- Statistical methods: Student t
test and Yate’s continuity corrected χ-square
- Definition:
- Biochemical pregnancy: blood β-hCG > 5mIU/mL
- Clinical pregnancy: gestational
sac observed under ultrasound at 6-8 weeks of pregnancy
- Ongoing pregnancy: pregnant
after 5 months
- Implantation rate: gestational
sac or fetal heart beat (FHB) per transferred embryo
Conclusions
Our
preliminary data suggested that:
1.
Vitrification
had no obvious adverse effect on embryos. In fact, it could be beneficial to
increase cumulative pregnancy rate.
