Why do I have miscarriages over and over again?
11/25/2018 04:22:00 PM
Being pregnant can be as a duck takes to
water, however for many people, it can be easily achieved, but how to "safely
reach full-term" seems to be a challenge that is harder than climbing up
to the sky.
"Why do I have miscarriages over and
over again?"
After having the examination, we found out
that some mothers have problems with the immune system that is easy to attack
the blastocyst and cause the miscarriage.
The process of pregnancy is a well-designed
by the God. The reason why the blastocyst isn’t attacked by the immune system
is mainly the barrier formed by the placenta between the fetus and the mother, which
can make the immune system unable to identify the fetus as a foreign substance.
Through the effect of hormones, the
blastocyst can peacefully coexist with the mother. The mechanism involved in
the process is very complicated. As long
as one of them goes wrong, it will destroy the mechanism and allowing the
immune system to produce antibodies against the blastocyst during pregnancy. Usually
this immunoreaction may be normal before pregnancy.
Once pregnant, the defense mechanism begins to be so problematic that the blastocyst cannot continue implanting and cause abortion.
Once pregnant, the defense mechanism begins to be so problematic that the blastocyst cannot continue implanting and cause abortion.
In general, there are many autoimmune
diseases have a strong relationship to habitual abortion such as Antiphospholipid
syndrome (APS), Systemic Lupus Erythematosus (SLE), Thrombotic Thrombocytopenic
Purpura (TTP) and so on.
Due to the problem of the immune system, it is easy to form the thrombus, block up the blood vessels of the placenta, and cannot supply nutrients to the fetus. Or it can cause the placenta itself to become inflamed, produce antibodies to attack the blastocyst and lead to abortions.
Due to the problem of the immune system, it is easy to form the thrombus, block up the blood vessels of the placenta, and cannot supply nutrients to the fetus. Or it can cause the placenta itself to become inflamed, produce antibodies to attack the blastocyst and lead to abortions.
In recent years, it has been discovered that there is an immunocyte in the mother's body called "natural killer cell (NK cell)". Under normal conditions, this immunocyte which is produced by the bone marrow in the blood plays the first line of defense to protect the human body. Induced by the thymus gland, it can attack foreign bacteria and viruses, or kill tumor cells. In addition to the NK cells in the blood, there are NK cell also existed in the uterus. Basically, the NK cells in the uterus are different from the one in the blood. It can not only avoid inflaming but also having considerable benefits for implantation. However, if there are excessive NK cells in the uterus, it may cause infertility or abortion.
Therefore, except for the examination of
immune diseases such as complement system (C3, C4), antinuclear antibody (ANA),
antiphospholipid antibody (APA) and anticardiolipin antibody (ACA), the
concentration of NKcells in the uterus can be included in one of the examination
items for habitual abortion.
As long as the concentration of autoantibodies
in the body is too high, it's necessary to treat with the medication before pregnancy.
The medication is including Aspirin, Steroid, Immunosuppressive drug or Heparin
and some patients are suitable the Immune Globulin and Cancer Immunotherapy.
However, it's still a mystery in the medical field that what reasons cause the immunocyte to attack the blastocyst. Therefore, the immune problems and related treatments still need to be evaluated by professional physicians. To increase the pregnancy rate, it’s necessary to deal with it.
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WhatsApp：+886-905-737-501The Grand Opening of our Branch in Taipei City - Stork 11
11/08/2018 01:54:00 AM
Back to the future - the secret of 11
With the anticipation
by all of the customers of Stork Fertility Center, The grand opening of Stork
11 (Taipei branch) is finally launching! Everything has its own reason. Why we
decided to set up a branch? Why we named it Stork 11? And what is our expectation toward Stork 11?
The story began from
the financial crisis of 2008. At that time, we launch our egg collection (EC)
and blastocyst collection (BC) treatments, two accumulative strategies of
oocytes and blastocytes. By means of these two treatments, we encourage our
customers with diminished ovarian reserve (DOR) to speed up their path of
having a baby. The ideas popped up one day when I was on my way to Starbucks
across the street. Surprisingly, I realized the Starbucks, which never has any
discount, was having a buy one get one free campaign to overcome the economical
distress. During that period of time, I always remind my employees that
"getting something to do is better than nothing to do", in case they
were fooling around during work time.
The concepts of
"similar protocol treatment" and "doing more than we could"
became a motivation to help our customer, especially for those who had only 1
to 2 eggs at a cycle, to save the cost of the IVF treatment. After finishing
the collection of more than 6~10 mature eggs, they can consider thawing the sperm
and performing the insemination at once. This strategy could not only hugely
save the cost of treatment but also ease the mental burden of our customer.
Most importantly, this act also meets the belief of Stork Fertility center: Helping
others may amazingly lead to great self accomplishment.
Since our treatment
designs were originated from the customer perspective, our treatments attracted
many DOR customers in a very short period of time. As for those who are going
to give up and considering the oocyte recipient program, most of them are
living in Taipei city with age over 40. I was particularly struck by a case; a
47-year old lady got pregnant and gave birth to her daughter by using her own
eggs. Besides her miraculous story, many of our customers with the age of 45
also got pregnant by receiving the treatment in Stork Fertility center.
However, some of them can only consider the oocyte recipient program in order to
successfully reach the pregnancy. With the accumulation of abundant cases, our
experience also indirectly boosted the development of our oocyte bank and
oocyte cryopreservation business.
One of our case,
Miss S, is a career motivated 37-year old female from the US. Although her AMH
value is only 0.79, she never consider giving up on the idea of being a mother.
She flew to Taiwan for treatments and 5 times oocyte pick-up operations,
because she strongly believes that she can one day realize her dream. For now,
she already has 12 mature oocytes for future use.
According to the
statistic here in Stork Fertility center, In 2017, we thawed 326 case of
donated oocytes from our oocyte bank, which were 5,493 mature oocytes in total.
With the survival rate of 94% after thawing, 5,136 oocytes were survived. The
fertilization rate is 78% (3,983 embryos), and the good blastocyst rate is 54%
(2,133 blastocysts). To sum up, 1 good blastocyst can be created by only using
2.86 mature oocytes in average. The high quality performance and outstanding oocyte
survival rate after thawing are owing to not only the leading laboratory
techniques but also the strict selection of the ooctye donors (only 8 out of
100 girls could pass the criteria of oocyte donor).
According to the Stork
Fertility center Happiness Pregnancy code (P code), female below age of 37 with
15 mature oocytes will acquire 90% of chance to bring a baby home in the
future. This means that the dream of Miss. S is definitely worth expecting. The
statistic analysis shows that about 13 oocytes will survive after thawing 14
oocytes with no accident. The survived oocytes will lead to 10 fertilized eggs and 5 good blastocysts in the
following procedure. The euploid rate of blastocyst for age 35-37 is 43.8%. The
pregnancy rate can increase to 60-70% after the Preimplatation Genetic Screening
(PGS). What's more, the pregnancy rate can even increase to 70-80% if you also
do the Endometrial Receptivity Analysis (ERA, third generation plus). With the
personalized precision IVF treatment (PP-IVF), the successful rate of
implanting 1 blastocyst with third generation plus examination is 80%. By all
these evidences, you will understand what a great chance for Miss. S to fulfill
her dream of having a baby in the future.
The future is decided by now! Will you
believe in yourself if you are a 35-37 year-old female just like Miss. S? If
being a mother is the deepest dream of yours, why don't you start collecting
your young oocytes from now? Saving 15 mature eggs as a present for you in the
future is also a prevention from being a oocyte recipient and waiving away
large amount of money.
Located in Hinschu, in Stork Fertility
center, there are about 40% of our customers are from Taipei (foreign customers
are also the same amount). Our Taipei branch- Stork 11 finally comes to
realization after 10 years of anticipation from our customers. "11"
indicates our commitment to all the female below age of 35 (35 is not included)
. With 11 mature oocytes cryopreservation, you will have 90% of probability to
bring back a baby in the future. Our definite goal is to help everyone realize
the happiness and dream of having a baby in your family.
Stork 11 is also a building of Nara.
With the combination of our company culture and spirit of art, we also welcome
people who love Yoshitomo Nara (奈良美智/ならよしとも)
to visit Stork 11.
Stork 11 will also
inherit the DNA of Stork Fertility center. We will continuously provide prestigious
services in the future.
~wrote by Dr. Hsing-Hua Lai, Dean of Stork Fertility Center
~wrote by Dr. Hsing-Hua Lai, Dean of Stork Fertility Center