Should I perform IVF 3.0+ plus (ERA+PGS)?

How to create an IVF baby with a high pregnancy rate, spent a lot of money, always hope to succeed at one time, check so many items, which one is right for me? Should I do it?

The answer that almost every infertile client wants to know how to create an IVF with a high pregnancy rate. After spending a lot of money, I always hope to succeed at one time. Among so many inspections, are they all what I need? Personalized IVF tells that there is no absolute answer to medical treatment. Only after non-guided consultation, a mutually agreed plan is the best plan.

This article will discuss the most popular IVF 3.0+ (PGS+ERA) recently. What is IVF 3.0+? That is, through in vitro fertilization, the sperm and eggs are combined in vitro and cultured. Through chromosome screening (PGS), embryos implanted are with normal chromosomes; and the optimal implantation window (ERA) of the maternal endometrium is found through the molecular platform of gene expression, then personalized embryo transfer(pET) at the timing.

The following data was mentioned in the 2019 Taiwan Reproductive Medicine Symposium. About 42% of IVF failures are caused by abnormal embryonic chromosomes, 12% are due to differences in the implantation window, and 18% are due to chromosomal abnormalities plus wrong transfer window. The remaining 28% of the errors are other reasons that have yet to be identified, as shown in the figure below.

The main reason for embryo chromosomal abnormalities usually comes from errors in meiosis of older eggs, rather than the traditional chromosomal inheritance from parents. The second major reason is the difference in embryo implantation windows. A successful IVF requires implantation at the right time in addition to normal embryo chromosomes, which is the so-called window of implantation (WOI).

According to the above figure, 72% of the failures of IVF are caused by chromosomal abnormalities or different bed windows. Therefore, after eliminating these two main causes, a higher success rate will be obtained.

Is it suitable for me to do PGS+ERA? The following chart tells us.

Non-P/Non-E means no embryo chromosome check and no implantation window check.
Non-P/E means no embryo chromosome check and the implantation window examination has been done.
P/E means embryo chromosome check and the implantation window examination both have been done.

When the age of the egg is >38 years old, it reveals that the pregnancy rate of the implanted chromosomes normally goes with the correct implantation window is much higher than that of the group without embryo chromosome examination and implantation window examination.

Through the two graphs shared in the seminar, it is clear that when the egg is older than 38 years old, it is strongly recommended to perform PGS+ERA, which can greatly increase the pregnancy rate.

And what about the egg age less than 38 years old? According to Stork's experience, although the decline of the egg age helps to obtain a higher proportion of normal embryo chromosomes, and the proportion of abnormal implantation windows does not increase significantly (compared with the elderly group), but Who wants to be a gambler? If you want to be more than 90% sure, further inspections are not a must, and up to 72% of IVF failures are due to embryonic chromosomes and implantation windows. Summarize the following guidelines for your reference, choose the most suitable plan, consider the embryo count and psychological and financial factors, and select the best personalized IVF.

The following is a summary of the customers who are strongly recommended to perform IVF 3.0+(PGS+ERA):