Lab Touring - PGS, Preimplantation Genetic Screening by next-generation sequencig (NGS)
7/13/2015 01:27:00 AM
The traditional prenatal examinations include chorionic villus sampling (CVS) and amniocentesis. However, the induction would be required if either CVS or amniocentesis revealed significant chromosomal abnormalities, and it becomes psychological stress. Perimplantation Genetic Screening（PGS）is an advanced technology, combining IVF and cell molecular biology, taking the third day embryo (about 6-10 cells now) or the 5th day blastocyst cell for chromosome analysis. The widely used analysis platform is based on array comprehensive hybridization (aCGH), but the recent researches reported that the next-generation sequencing platform performs better resolution and sensitivity. In addition, the low-rate aneuploidy is displayed more clearly in the NGS than in the aCGH.
Technique
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NGS
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aCGH
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Resolution
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Diagnosed
range: affected length>10Mb
Detected
range: affected length >2Mb
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Diagnosed
range: affected length>10Mb
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Application
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1.
Frequent early abortion
2.
Repeated failure in IVF
3.
Advanced maternal age
4.
Undefined infertility
5.
Severe male infertile factor
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Embryo stage
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D5/D6
good blastocyst (≧BB)
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Accuracy
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90%
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90%
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Embryo transfer
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Warmly
thawed embryo transfer
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Prenatal exam
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Amniocentesis is recommended
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Amniocentesis is recommended
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The aneuploid rate increases with the maternal age.
The general exam procedure of PGS is showed in the following figure,
Do you have any genetic disorders that you’re worried your child might inherit? Now, you can avoid making painful decisions, thanks to PGD testing. In Mumbai, IVF Spring is one of the leading clinics for PGD and PGS testing, in which the embryos collected during the IVF cycle are tested for various inherited disorders, and embryos that have the gene are not considered for implantation. This helps prevent genetic birth defects in children. PGD tests for a specific disease, which is great for parents who carry specific genetic disorders. PGS is more general, and tests for various disorders, which is normally recommended for mature couples, as well as women who face multiple miscarriages, to determine the cause. Our team of expert doctors work together to diagnose issues, as well as perform treatment procedures. Our success rates are among the highest in the market, along with a 96% satisfaction rate from our clients. We believe in personalized and customized care, where couples can freely come to us with queries or concerns, so that treatment is easy and stress free. Choose IVF Spring for your PGD and PGS testing, and ensure that your child has the best possible quality of life.
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