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IVF success 'downhill from age 37' finds Aberdeen study

The chances of a woman having a baby following IVF go "very rapidly downhill" from the age of 37, according to a study.

The University of Aberdeen study reports a woman's age affects the outcome of every single step of IVF. Researchers studied data from 121,744 women from across the UK.

We found that age impacted on every single hurdle that has to be overcome during the emotional rollercoaster that is IVF”Prof Siladitya BhattacharyaUniversity of Aberdeen
They found the chances of having a baby following IVF start to decline by the time the woman reaches her mid-30s, but especially from 37. The team used data from women who underwent their very first cycle of IVF between 2000 and 2007 using their own eggs. The research found that even after a pregnancy has been confirmed, women aged 38-39 were 43% more likely to have a miscarriage than women aged 18-34, while women aged 40-42 were almost twice as likely to lose the baby as the younger age group.

Prof Siladitya Bhattacharya, of the Reproductive Medicine team at the University of Aberdeen who led the research, said: "IVF comprises a number of key steps, each of which has to be successfully achieved before the next stage can be attempted.
"We found that age impacted on every single hurdle that has to be overcome during the emotional rollercoaster that is IVF.

"This influence of age is sustained at each stage of the IVF process.

"There is no point during an IVF treatment - even in women who have done well in a preceding stage - when age ceases to matter.

"Age has the capacity to increase the risk of treatment failure even in women who respond to hormonal treatment, have eggs harvested and embryos replaced."

'Dynamic' prediction
He concluded: "Many couples want to understand how their chances of having a baby evolve over the course of an IVF treatment.

"Previous work has been able to offer a global prediction of success in IVF.

"We hope our study provides a more accurate and dynamic way of predicting a couple's chances of treatment failure as they negotiate each step of IVF."


The relationship between maternal age and pregnancy rate:
1. In Taiwanese records, 38 years is the crucial cut-off point to achieve a successful pregnancy. Based on the report of Taiwan Ministry of Health and Welfare in 2007 to the women those undergoing IVF program, the pregnancy rate of the women under 35 years was 45.8%, and that of the women over 40 years was 14.8%; the live birth rate of the women under 35 years was 35.9%, and that of the women over 40 years was 7.4%. The most important factor to the quality of ovaries and eggs is maternal age.

2. The solution to overcome the diminished ovarian decline is to "freeze the eggs" beforehand. If we can store our eggs through the recent cryo technique, we can arrange our life schedule flexibly and decrease the expenses to get pregnancy in the future.

How to choose the most appropriate clinical center to store my eggs?

1. Center with higher pregnancy rate in IVF realm
2. Annual cycles of frozen-thawed embryo transfer over 100, and live birth rate over 40%
3. Professional manager team
4. Individual storage space
5. Annual frozen-thawed case report

Stork Fertility Center Stork Fertility Center Author


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