First successful pregnancy after preimplantation genetic diagnosis for Hemophilia A in Asia
8/08/2013 12:32:00 AM
First successful pregnancy after preimplantation genetic diagnosis for Haemophilia A in Asia
| Author | Hsing-Hua Lai, Huai-Ling Wang, Shih-Chieh Huang, Wen-Yi Chiang |
|---|---|
| Editor | Hui-Ling Kao |
| Seminar name | 2010 TSRM |
| Keyword | PGD, inherited disease, IVF |
| PDF download |
Haemophilia A, the most common X-linked disorder affecting males, results from deficient or defective coagulation factor VIII which impairs the coagulation cascade (Fig. 1) and causes bleeding symptoms. In Taiwan, there are about 1000 haemophilia patients, where the cost on medication is 2,300 million dollars per year. Different types of factor VIII gene mutation have been characterized and among which, intron 22 inversion is the most seen and responsible for 45% of severe HA cases.
The conventional way for HA patients to have an unaffected child is to play “reproductive roulette” and give up all male babies. Preimplantation genetic diagnosis (PGD) provides an alternative strategy for couples carrying HA to conceive a healthy child without sex selection hence to reduce the mental pressure and medical cost. This technique can be performed on blastomere or trophectoderm cells. The DNA in each cell is analyzed for a specific gene mutation, i.e. factor VIII gene in HA. In recent years, the need of PGD for HA is increasing.
The Nobel Prize in Physiology or Medicine 2010 --- Robert G. Edwards
10/04/2010 09:20:00 PM
Robert Edwards is awarded the 2010 Nobel Prize for the development of human in vitro fertilization (IVF) therapy. His achievements have made it possible to treat infertility, a medical condition afflicting a large proportion of humanity including more than 10% of all couples worldwide.
Nobel Prize Awarded to Developer of In Vitro Fertilization
10/04/2010 08:48:00 PM
by Robert Lowes
From Medscape Medical News
October 4, 2010 — It is hard to deny a scientist a Nobel Prize when there are 4 million good reasons.
In the case of Robert Edwards, PhD, who was awarded the 2010 Nobel Prize in medicine or physiology today, the reasons are roughly 4 million people born over the past 32 years due to the therapy he is being honored for — in vitro fertilization (IVF).
e-Stork helps hemophilia carrier have healthy child
5/03/2010 03:45:00 AM2010/04/29 20:11:31
Taipei, April 29 (CNA) A biotechnology company in Taiwan said Thursday that it has helped a local woman who carries the hemophilia gene to conceive a baby who will not suffer from hemophilia -- a genetic disease that makes bleeding uncontrollable -- and hailed it as the first case in Asia.
Taipei, April 29 (CNA) A biotechnology company in Taiwan said Thursday that it has helped a local woman who carries the hemophilia gene to conceive a baby who will not suffer from hemophilia -- a genetic disease that makes bleeding uncontrollable -- and hailed it as the first case in Asia.